剖宫产史对体外受精-胚胎移植治疗结局的影响

目的：探讨剖宫产史对体外受精-胚胎移植（IVF-ET）治疗结局的影响。方法：回顾性分析2019年1月至2019 年12月温州医科大学附属第二医院育英儿童医院生殖中心接受IVF-ET的患者，根据患者的分娩史分为仅有阴道分娩史组（292例）和剖宫产史组（311例），比较2组胚胎植入成功率及治疗结局等。结果：剖宫产史组的胚胎植入成功率低于仅有阴道分娩史组（P ＜0.05）。2组间的流产率、双胎率、异位妊娠率差异无统计学意义（P ＞0.05）。2组间早产、死产、出生体质量、出生缺陷、胎盘前置和产后出血等指标差异无统计学意义（P ＞0.05）。结论：剖宫产史影响了IVF-ET再妊娠的胚胎植入成功率，但剖宫产史对患者的流产率等治疗结局无明显影响。

The effect of prior cesarean section on outcomes of in vitro fertilization-embryo transfer

Objective: To investigate the effect of prior cesarean delivery (CD) on the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET). Methods: Clinical data of women who underwent IVF-ET in the assisted reproduction technology center of the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from January 2019 to December 2019 were retrospectively analyzed. According to their delivery history, patients with a history of live birth by CD were assigned to the CD group (n=292), and those with only vaginal delivery (VD) were categorized into the VD group (n=311). The embryo implantation rate and treatment outcomes were compared between the two groups. Results: The embryo implantation rate of VD group was significantly higher than VD group (P<0.05). However, there was no statistical difference in miscarriage rate, twinning rate and incidence of ectopic pregnancy between the two groups, neither in indexes of premature, stillbirth, birth weight, birth defects, placenta previa and postpartum hemorrhage. Conclusion: A prior CD does affect the embryo implantation rate, but it is not associated with increased risk of miscarriage and other adverse treatment outcomes in IVF patients.