羟基红花黄色素A防治耳鸣的实验研究

目的 利用水杨酸钠诱发的小鼠耳鸣模型研究羟基红花黄色素A对耳鸣的防治作用。方法 24只小鼠随机分成3组,分别给予腹腔注射生理盐水(0.4 mL)、水杨酸钠(400 mg/kg)、水杨酸钠(400 mg/kg)联合羟基红花黄色素A(20 mg/kg)腹腔注射,每日1次,连续注射3 d。完成给药2 h后检测小鼠听觉惊跳反应幅度之比,背景噪声分别为8和16 kHz窄带噪声。结果 水杨酸钠注射组小鼠出现了明显的耳鸣样行为;在16 kHz,水杨酸钠联合羟基红花黄色素A注射组听觉惊跳反应幅度之比较水杨酸钠注射组明显降低(P<0.05)。结论 羟基红花黄色素A可以有效地防治水杨酸钠引起的耳鸣。

The study of the treatment of tinnitus with hydroxysafflor yellow A

Objective To study the effect of hydroxysafflor Yellow A(HSYA)on the salicylated-induced tinnitus. Methods Twenty-four mice were divided into three groups, which were given respectively normal saline (0.4 mL), sodium salicylate (400 mg/kg) and sodium salicylate combined with HSYA (20 mg/kg) by peritoneal injection (i.p.) one time a day for 3 days continuous. After 2 h of administration, the ratio of acoustic startle (AS) response amplitude was detected, and the background noise were 8 and 16 kHz narrow-band noise. Results The mice in sodium salicylate injection group showed obvious tinnitus-like behavior. At 16 kHz, compared with the sodium salicylate group, the amplitude of AS response of mice in the sodium salicylate combined with HSYA group was significantly decreased(P<0.05). Conclusion HSYA can effectively prevent tinnitus caused by sodium salicylate.