灯盏细辛注射液联合胞二磷胆碱对老年急性缺血性脑卒中患者脑血循环的影响

目的 探究灯盏细辛注射液联合胞二磷胆碱对老年急性缺血性脑卒中患者脑血循环及TLR4/核因子-κB(NF-κB)信号通路相关蛋白表达的影响。方法 选取2017年8月至2019年7月陕西省第二人民医院150例老年急性缺血性脑卒中患者作为研究对象,简单随机分为3组,各50例。对照A组予以胞二磷胆碱治疗,对照B组予以灯盏细辛注射液治疗,观察组予以灯盏细辛注射液联合胞二磷胆碱治疗。统计对比三组临床疗效、治疗前、疗程结束后神经功能(NIHSS)评分、Barthel指数、血流速度(Vm)、阻力指数(RI)、血管搏动指数(PI)、血浆黏度、全血黏度、红细胞聚集率、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、TLR4/NF-κB信号通路相关蛋白。结果 观察组临床疗效高于对照A、B组(P＜0.05);观察组疗程结束后NIHSS评分低于对照A、B组,Barthel指数高于对照A、B组(P＜0.05);疗程结束后,观察组Vm水平高于对照A、B组,PI、RI、血浆黏度、全血黏度、红细胞聚集率低于对照A、B组(P＜0.05);疗程结束后,观察组血清MDA水平低于对照A、B组,SOD水平高于对照A、B组(P＜0.05);疗程结束后,观察组TLR4、NF-κB蛋白表达低于对照A、B组(P＜0.05)。结论 灯盏细辛注射液联合胞二磷胆碱治疗老年急性缺血性脑卒中,可显著改善患者血流动力学、血液流变学,抑制氧化应激反应,调节TLR4/NF-κB信号通路,促进神经功能恢复,提高日常生活活动能力,效果较为显著。

Effects of Erigeron breviscapus injection combined with citicoline on cerebral blood circulation in elderly patients with acute ischemic stroke

Objective To investigate the effect of Erigeron breviscapus injection combined with citicoline on cerebral blood circulation and TLR4/NF-κB signaling pathway in elderly patients with acute ischemic stroke.Methods From August 2017 to July 2019,150 elderly patients with acute ischemic stroke in our hospital were selected as the research objects,and they were simply randomized into three groups,each with 50 patients.Control group A was treated with citicoline,control group B with breviscapine injection,and observation group with breviscapine injection and citicoline.The clinical efficacy,NIHSS score,Barthel index,blood flow velocity (VM),resistance index (RI),vascular pulsation index (PI),plasma viscosity,whole blood viscosity,erythrocyte aggregation rate,serum superoxide dismutase (SOD),malondialdehyde (MDA),TLR4/NF-κB signaling pathway related proteins of the three groups were compared before and after treatment.Results The clinical efficacy of the observation group was higher than that of the control A and B groups (P＜0.05); the NIHSS score of the observation group was lower than that of the control A and B groups and the Barthel index was higher than that of the control A and B groups (P＜0.05); after the treatment course,the Vm level in the observation group was higher than that in the control A and B groups,and the PI,RI,plasma viscosity,whole blood viscosity,and red blood cell aggregation rate were lower than those in the control A and B groups (P＜0.05);after the end of the treatment period,the serum MDA level in the observation group was lower than that in the control A and B groups,and the SOD level was higher than that in the control A and B groups (P＜0.05); after the treatment period,the expressions of TLR4 and NF-κB protein in the observation group were lower than those in the control A and B groups (P＜0.05).Conclusion Erigeron breviscapus injection combined with citicoline in the treatment of senile acute ischemic stroke,which can significantly improve the hemodynamics and hemorheology of patients,inhibit oxidative stress,regulate TLR4/NF-κB signal pathway,promote the recovery of nerve function,and improve the ability of daily life activities,the effect is significant.