阿达帕林凝胶辅助超分子水杨酸、类人胶原蛋白敷料治疗轻中度痤疮患者的效果观察

目的 探讨阿达帕林凝胶辅助超分子水杨酸、类人胶原蛋白敷料治疗轻中度痤疮患者的效果及对皮肤屏障功能、美容满意度的影响。 方法 选取我院收治的轻中度痤疮患者123例，按照随机数字表法分为3组，各41例。对照A组采取超分子水杨酸、类人胶原蛋白敷料治疗，对照B组采取阿达帕林凝胶治疗，观察组采用阿达帕林凝胶辅助超分子水杨酸、类人胶原蛋白敷料治疗。比较3组治疗效果、症状改善时间、治疗前后皮损情况、皮肤屏障功能指标［皮肤经皮水丢失（transepidermal water loss，TEWL）、角质层含水量、pH值］、美容满意度及不良反应发生情况。 结果 观察组总有效率高于对照A组和对照B组（P＜0.05），对照A组与对照B组比较差异无统计学意义（P＞0.05）。观察组红斑持续时间、疼痛持续时间、结痂时间、痂皮完全脱落时间短于对照A组和对照B组，对照A组短于对照B组（P＜0.05）。治疗4周后，3组丘疹、粉刺、脓包、结节囊肿数目少于治疗前，观察组少于对照A组和对照B组，对照A组少于对照B组（P＜0.05）；3组TEWL、角质层含水量、pH值优于治疗前，观察组优于对照A组和对照B组，对照A组优于对照B组（P＜0.05）。观察组美容满意度高于对照A组和对照B组（P＜0.05），对照A组与对照B组比较差异无统计学意义（P＞0.05）。3组不良反应发生率比较差异无统计学意义（P＞0.05）。 结论 阿达帕林凝胶辅助超分子水杨酸、类人胶原蛋白敷料治疗轻中度痤疮效果显著，患者满意度高，且具有安全性。

Clinical observation of Adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressing in the treatment of patients with mild to moderate acne

Objective To investigate the effect of adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressings in the treatment of patients with mild to moderate acne and its influence on skin barrier function and the cosmetic satisfaction.Methods A total of 123 patients with mild to moderate acne admitted to our hospital were selected and divided into three groups according to the random number table method, with 41 cases in each group. The control group A was treated with supramolecular salicylic acid and human-like collagen dressing, the control group B was treated with adapalene gel, and the observation group was treated with adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressing. The therapeutic effect, time of symptom improvement, skin lesions, and skin barrier function indexes［transepidermal water loss(TEWL), stratum corneum water content, pH value］ before and after treatment, the cosmetic satisfaction and adverse reactions were compared among three groups.Results The total effective rate of the observation group was higher than that of control group A and control group B(P＜0.05). There was no significant difference between control group A and control group B(P＞0.05). The duration of erythema, pain, scab formation and complete shedding of scab in the observation group were shorter than those in control group A and control group B, and the above indicators in control group A were shorter than those in control group B(P＜0.05). At 4 weeks after treatment, the number of papules, acne, abscess, nodules and cysts in the three groups was less than that before treatment, and the number was less in observation group than in the control group A and control group B, and less in the control group A than in the control group B(P＜0.05). The TEWL, stratum corneum water content and pH value in the three groups were better than those before treatment, and the above indicators were better in the observation group than in control group A and control group B, and better in the control group A than in control group B(P＜0.05). The cosmetic satisfaction of the observation group was higher than that of control group A and control group B(P＜0.05), while there was no significant difference between control group A and control group B(P＞0.05). There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion Adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressings are effective in treating mild to moderate acne, with good patient satisfaction and safety.