西沙比利对不同透析方式患者的消化道症状及胃肠激素影响研究

目的:研究西沙必利对HD和PD患者消化道症状及胃肠激素的影响。方法:选取透析患者120例作为研究对象，同期选择40位健康人作为对照组，在给予基础疾病的常规治疗基础上加用西沙必利治疗，对比血清生长抑素（SS）、胃动素（MOT）及血管活性肠肽（VIP）水平，以及消化道症状、胃肠激素和部分生化指标的变化。结果:治疗后，HD组和PD组患者消化道症状评分显著低于治疗前（P＜0.05），治疗后PD组在腹胀和便秘症状得分仍高于HD组；HD组和PD组治疗前后SS和VIP无显著变化（P＞0.05），MOT显著下降（P＜0.05）；PD组和HD组治疗前后BUN、Scr、Hb和kt/v对比无显著差异（P＞0.05），而PD组ALB水平治疗后较治疗前升高（P＜0.05）。研究组胃肠激素水平明显高于健康对照组。结论:透析患者都普遍存在消化道症状，且存在明显的胃肠激素蓄积，在常规基础疾病治疗的基础上加用西沙必利可以改善其消化道症状效果，同时降低患者血清胃动素含量。

Effects of Cisapride on symptoms of digestive and gastrointestinal hormones in patients with different dialysis modes

Objective: To study the therapeutic effect of Cisapride on symptoms of digestive and gastrointestinal hormones in different dialysis patients. Methods: There were 120 cases of dialysis patients being selected as the study group in this paper , and they were additionally treated with cisapride on the base of being given routine treatment of the underlying disease. 40 healthy peoples were selected as the control group. The gastrointestinal symptoms, serum somatostatin（SS）, motilin（MOT）andvasoactive intestinal peptide（VIP）and renal function and biochemical indexes were compared before and after treatment in HD group and PD group. Gastrointestinal hormones were compared with the control group. Results: The score of gastrointestinal symptoms were significantly lower after treatment than before (P＜0.05). After treatment, the scores of abdominal distension and constipation in PD group were still higher than those in HD group;There was no significant change between before and after treatment in BUN、Scr、Hb、kt/v、SS and VIP in PD group and HD group(P＞0.05)，but the MOT were decreased significantly(P＜0.05) ，and the level of ALB in PD group increased after treatment (P＜0.05). The level of gastrointestinal hormones in the study group was significantly higher than those in the healthy control group. Conclusion: gastrointestinal symptoms are common in dialysis patients, and there is obvious accumulation of gastrointestinal hormones, which leads to gastrointestinal dysfunction. Conventional treatment combined with Cisapride can improve the effect of gastrointestinal symptoms in these patients，while reducing serum motilin levels.