液体活检在结直肠癌诊断中的应用进展

结直肠癌(Colorectal cancer,CRC)作为全球第三大常见癌症,是导致人类死亡的重要原因之一。目前针对CRC的诊断手段仍在不断完善,液体活检作为一种新兴的无创活检组织检查技术,受到广泛关注。液体活检主要对生物源液体特定成分进行分析,其中主要包括循环肿瘤细胞、循环肿瘤DNA、细胞游离DNA、外泌体、肿瘤相关血小板及循环肿瘤相关微粒等。本文就以上生物源液体特定成分在CRC诊断中的最新应用研究进行综述。

Application progress of liquid biopsy in the diagnosis of colorectal cancer

Colorectal cancer(CRC),as the third most common cancer in the world,is one of important cause of human death.At present,the diagnostic methods for CRC are still being improved.Liquid biopsy,as an emerging non-invasive biopsy technology,has attracted widespread attention.Liquid biopsy mainly analyzes specific components of biological source liquid,which mainly include circulating tumor cells,circulating tumor DNA,cell free DNA,exosomes,tumor-educated platelets,and circulating tumor-associated microparticles.This article reviews the latest application research of the above biological source liquid specific components in the diagnosis of CRC.