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| 晶体源性眼内炎发病机理的实验研究——植物血凝素对晶体蛋白免疫耐受性的破坏作用 | |
| 引用本文： | 赵伟,何淑芳,孙笑熳. 晶体源性眼内炎发病机理的实验研究——植物血凝素对晶体蛋白免疫耐受性的破坏作用[J]. 眼科研究, 1990, 0(1) |
| 作者姓名： | 赵伟 何淑芳 孙笑熳 |
| 作者单位： | 第二军医大学长海医院眼科，第二军医大学长海医院眼科，第二军医大学长海医院眼科 上海 200433，上海 200433，上海 200433 |
| 摘 要： | 依据植物血凝素(PHA)能激活多克隆T淋巴细胞的性质,先给大鼠注射PHA,再切开晶体囊膜,大鼠发生了晶体源性眼内炎。这个结果直接证实了T淋巴细胞在晶体源性眼内炎发病过程中起始动作用。这一动物模型建立时间短,不需接种弗氏佐剂,有助于探讨该病的发生机理和寻找治疗药物。 |
| 关 键 词： | 植物血凝素 晶体源性眼内炎 T淋巴细胞 低剂量免疫耐受 大鼠 |
Phytohemagglutinin-triggered Experimental Lens-induced Endophthalmitis in Rats |
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| Zhao Wei and He Shufang. Phytohemagglutinin-triggered Experimental Lens-induced Endophthalmitis in Rats[J]. Chinese Ophthalmic Research, 1990, 0(1) | |
| Authors: | Zhao Wei and He Shufang |
| Affiliation: | Zhao Wei and He Shufang Department of Ophthalmology,Changhai Hospital,Shanghai |
| Abstract: | An experimental lens-induced endophthalmitis (LE) was produced after in jury to the lens of rats previously given i.p. with phytohemalglutinin(PHA).This result directly shows the starting role of T cell in the development of LE. The PHA-triggered LE is easily produced in a short period of time with out the need of injection of lens protein and Fr eund's adjuvant, therefore, it perhaps helps us further to study the mechanism of the disease and determine the effects of some drugs on modulating the inflammation in LE by this animal model. |
| Keywords: | phytohemagglutinin lens-induced endophthalmitis T-lymphocyte lowzone tolerance rat. |
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