急性脑梗死伴短暂性脑缺血发作的降纤治疗观察

目的 观察降纤酶治疗急性脑梗死伴短暂性脑缺血发作（TIA）的临床疗效。方法 52例脑梗死期间伴TIA发作的患者随机分成2组，治疗组（27例）用降纤酶5u加入0．9％生理盐水250ml静滴，连用7天，首剂加倍。对照组（25例）给予血栓通10ml加入0．9％生理盐水250ml静滴，连用15天。分别观察2组治疗前后血液学改变及临床疗效和TIA控制时间。结果 治疗组治疗后纤维蛋白原及血液粘度等明显降低，有显著差异（P〈0．05），且较对照组降低明显；在控制TIA发作及临床疗效上亦差异有统计学意义。治疗组不良反应轻微，未发现出血性脑梗死及粘膜活动性出血情况。结论 应用降纤酶通过调节纤溶系统，迅速控制TIA发作，从而阻断急性脑梗死的进展，降低致残率，且安全、实用。

Observation of defibrase treatment of acute cerebral infarction accompanying transient ischemic attacks

Objective To evaluate the effect of defibrase treatment of acute cerebral infarction（ACi） accompanying transient ischemic attacks（TIA）. Methods 52 patients with ACI accompanying TIA were randomly divided into two groups. In treatment group,27 patients were injected with defibrase 5u ＋ 0.9% NS. 250 ml ivdrip qdxT, And double injected in first day. In control group,25 patients were injected with xueshuantong 10 ml ＋0.9% NS 250 ml ivdrip qdxlS. The changes of blood,the treatment and TIA controlling time were observed in two groups. Results Fibrinogen and blood viscosity decreased significantly in treatment group（P 〈 0. 05） and the Controlling of TIA and treatment were superior to the control group too, The bad reactions were slight and no more hemorrhagic infarction and activity mucosa bleeding were discovered. Conclusion Defibrase treatment can regulate fibrinolytic system,control TIA quickly so that it can prevent ACI getting worse and reduce the disable rate. It＇ s safe and effective.