垂体性侏儒症患儿血脂及载脂蛋白A1,B水平

对25例垂体性侏儒儿的血胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C),低密度脂蛋白(LDL-C)、载脂蛋白A_1(Apo A_1)、载脂蛋白(Apo B)等进行了测定,并与相应健康儿作了比较;与此同时,还着重观察了基因重组人生长激素(hGH)治疗3个月后对患儿上述指标的影响。结果表明:(1)患儿组TC、TG、LDL-C和Apo B值均明显高于对照组(P分别<0.01、<0.05、<0.01和<0.01);其中TC值高于正常值上限者14例,占56％;TG升高者2例,占8％;Apo B升高者13例,占52％;而Apo　A_1水平较对照组明显降低(P<0.01)。(2)hGH治疗3个月后随访,患儿组的TC,LDL-C和Apo B水平较治疗前明显下降(P分别<0.05,<0.01和<0.01);而TG和Apo A_1水平皆有不同程度的上升(P<0.01)。提示垂体性侏儒儿存在着不同程度的脂质代谢紊乱,而生长激素缺乏是其主要原因之一。

THE SERUM UPID, APOLIPOPROTEIN A_1 AND B LEVEL IN PITUITARY DWARFISM

Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were analyzed in 25 cases of pituitary dwarfism with 30 age-matched healthy children as control. The effect of human growth hormone (hGH) therapy for 3 months on these indices were also observed.As a result, the mean values of TC, TG, LDL-C and Apo B in the patients were significantly higher than those in the control, while the mean Apo A1 value was below that of the control. After a 3-month hGH therapy, the TC, LDL-C and Apo B levels decreased significantly while TG and Apo At levels increased significantly. We concluded that lipid metabolic disorder existed to certain extent in patients with pituitary dwarfism and that growth hormone deficiency ,was the main cause of the disorder.