| 乳腺癌化疗前后血浆内皮素水平检测的临床意义 |
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| 引用本文： | 梁启廉,银正民,张英,揭育丽.乳腺癌化疗前后血浆内皮素水平检测的临床意义[J].肿瘤防治研究,2002,29(5):398-399,404. |
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| 作者姓名： | 梁启廉 银正民 张英 揭育丽 |
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| 作者单位： | 广东医学院附属医院,湛江,524001 |
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| 摘 要： | 目的 评价乳腺癌患者化疗前后血浆内皮素 1(Endothelin 1,ET 1)水平变化的临床意义。方法 采用放射免疫法检测 2 0例正常人及 4 5例乳腺癌患者化疗前后血浆ET 1水平 ,并作对比分析。结果 各期乳腺癌患者血浆ET 1水平明显高于正常对照组 (P <0 .0 1) ,Ⅳ期乳腺癌血浆ET 1水平明显高于Ⅲ期和Ⅱ期 ,Ⅲ期明显高于Ⅱ期 (P <0 .0 5 ) ,化疗后有效 (完全缓解和部分缓解 )患者血浆ET 1水平明显低于化疗前 (P <0 .0 5 )。结论 血浆ET 1水平与乳腺癌的发生发展有一定关系 ,血浆ET 1检测可作为乳腺癌治疗疗效和判断预后的一个监测指标。
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| 关 键 词： | 血浆内皮素-1 乳腺癌 化学疗法 放射免疫法 |
| 文章编号： | 1000-8578(2002)05-0398-02 |
| 收稿时间： | 2001-12-3 |
| 修稿时间： | 2001-12-25 |
Plasma endothelin in breast cancer before and after chemotherapy |
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| LIANG Qi-lian,YIN ZHeng-min,ZHANG Ying,et al Affiliated Hospital of Guangdong Medical College,Zhanjiang ,China.Plasma endothelin in breast cancer before and after chemotherapy[J].Cancer Research on Prevention and Treatment,2002,29(5):398-399,404. |
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| Authors: | LIANG Qi-lian YIN ZHeng-min ZHANG Ying Affiliated Hospital of Guangdong Medical College Zhanjiang China |
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| Institution: | LIANG Qi-lian,YIN ZHeng-min,ZHANG Ying,et al Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China |
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| Abstract: | Objective To evalue the value of plasma endothelin\|1(ET\|1) in predicting the prognosis of breast cancer patients before and after chemotherapy. Methods Radioimmunoassay was available to detect the level of plasma ET\|1 in 20 cases of normal control subject and 45 cases of patients with breast cancer before and after chemotherapy. Results Level of plasma ET\|1 were elevated in all subgroups of patients with breast cancer compared to the controls ( P <0.01), the plasma ET\|1 level in stage Ⅳ was hi... |
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| Keywords: | Plasma endothelin-1 Breast cancer Chemotherapy Radioimmunoassay |
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