母亲孕早期手机使用与婴儿夜醒行为队列研究

目的 描述孕早期母亲手机使用情况,探索孕早期手机使用与婴儿早期夜醒行为相关性。方法 于2015年2月至2016年8月在安徽省马鞍山市妇幼保健院围产门诊招募初次建册孕妇2 212名,随访至婴儿6月龄。孕晚期问卷调查中,1 779名孕妇报告了每日手机使用情况;婴儿夜醒行为报告为最近一周夜醒次数,由主要抚养人在6月龄问卷调查中填写,将平均每晚夜醒≥ 3次定义为夜醒频繁。应用多因素非条件logistic回归分析孕早期手机过度使用与夜醒行为的相关性。结果 出生队列中,2 212名孕妇年龄为（26.95±3.82）岁,随访至分娩共1 983名,其中男婴1 034名。1 951名家长报告了婴儿夜醒次数。6月龄婴儿中夜醒频繁发生率为28.3%（553/1 951）。孕早期使用手机"3~4 h/d"和"≥ 5 h/d"均与婴儿6月龄频繁夜醒正相关,在控制喂养因素后,调整后OR值（95%CI）分别为1.49（1.07~2.07）和1.79（1.31~2.46）。结论 孕早期手机过度暴露与婴儿夜醒频繁相关,提倡孕期合理使用手机。

Mobile phone use in early pregnant and infant sleep-wake behaviour in 6 months: a cohort study

Objective To describe the epidemiological characteristics of mobile phone use in early pregnancy, and to explore the relationship between pregnancy mobile use and infant sleep-wake behavior. Methods During February 2015 to August 2016, 2 212 subjects who had their first antenatal examination at Maanshan Maternity and Child Health Hospital were recruited in this cohort study and followed until postpartum for 6 months. Information of phone use was collected through questionnaire in the third trimester. There were 1 779 pregnant reported hours of mobile phone use in the questionnaire. A total of 1 951 parent reported the night-wake times. Data on night-wake behavior in infants was collected during the 6 months study. Questionnaires were completed by parents when taking the physical examination. More than 3 times per night was defined as the night-wake frequency. Unconditional multivariate logistic regression was applied to analyze the association of pregnancy time of mobile phone use and the infant night-wake frequencies. Results In this cohort study, the average age of 2 212 pregnant women was (26.95±3.82) years, with 1 983 of them were followed up to the time of delivery. The incidence of night-wake frequency was 28.3% (553/1 951) among these 6-month-old infants. After adjusted for feeding factors in the first trimester, frequencies of using the phone as "3 to 4 hour per day" and "5 hour and above per day" were both positively associated with the frequencies of night-wake behavior in infants. The adjusted OR (95%CI) were 1.49 (1.07-2.07) and 1.79 (1.31-2.46), respectively. Conclusions The mobile phone use during pregnancy was associated with night-wake of infants. Mobile phone should be rationally used during pregnancy.