| 出生季节与女性初潮年龄及绝经年龄的关联分析 |
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| 引用本文： | 司佳卉,孟若谷,吕筠,郭彧,卞铮,余灿清,杨玲,谭云龙,裴培,陈君石,陈铮鸣,李立明. 出生季节与女性初潮年龄及绝经年龄的关联分析[J]. 中华流行病学杂志, 2017, 38(7): 877-882 |
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| 作者姓名： | 司佳卉 孟若谷 吕筠 郭彧 卞铮 余灿清 杨玲 谭云龙 裴培 陈君石 陈铮鸣 李立明 |
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| 作者单位： | 100191 北京大学公共卫生学院流行病与卫生统计学系,100191 北京大学公共卫生学院流行病与卫生统计学系,100191 北京大学公共卫生学院流行病与卫生统计学系,100010 北京, 中国医学科学院,100010 北京, 中国医学科学院,100191 北京大学公共卫生学院流行病与卫生统计学系,OX1 3QR 牛津大学临床试验中心和流行病研究中心/纳菲尔德人群健康部,100010 北京, 中国医学科学院,100010 北京, 中国医学科学院,100020 北京, 国家食品安全风险评估中心,OX1 3QR 牛津大学临床试验中心和流行病研究中心/纳菲尔德人群健康部,100191 北京大学公共卫生学院流行病与卫生统计学系;100010 北京, 中国医学科学院 |
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| 基金项目： | 国家自然科学基金（81373082）；国家科技支撑计划（2011BAI09B01）；中国香港Kadoorie Charitable基金；英国Wellcome Trust（088158/Z/09/Z，104085/Z/14/Z） |
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| 摘 要： | 目的 分析出生季节与初潮年龄、绝经年龄及生育年限间的关联。方法 研究对象来自中国慢性病前瞻性研究的基线调查数据，剔除初潮年龄在生理范围外（<9岁或>18岁）的个体后，纳入285 186名女性进行初潮年龄相关分析；在已绝经的女性中排除因施行子宫切除术或卵巢摘除术绝经者，纳入132 373人进行绝经年龄及生育年限相关分析。统计分析采用多元线性回归模型。结果 在调整了可能的混杂因素后，与春季出生的女性相比，出生于夏、秋及冬季的女性初潮年龄平均晚0.14（95%CI：0.13~0.16）、0.26（95%CI：0.24~0.27）及0.10（95%CI：0.08~0.12）岁，绝经年龄依次晚0.14（95%CI：0.08~0.20）、0.18（95%CI：0.12~0.24）及0.09（95%CI：0.03~0.16）岁。生育年限与出生季节无关。上述关联在城市和农村地区、不同出生年代的女性中均是一致的。结论 出生于春季的女性初潮年龄及绝经年龄均更早。本研究结果提示生命早期某些与季节相关的因素可能会影响女性生殖系统的发育。
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| 关 键 词： | 出生季节 生命早期 初潮年龄 绝经年龄 生育年限 |
| 收稿时间： | 2016-12-12 |
Associations between season of birth and age both at menarche and at menopause |
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| Si Jiahui,Meng Ruogu,Lyu Jun,Guo Yu,Bian Zheng,Yu Canqing,Yang Ling,Tan Yunlong,Pei Pei,Chen Junshi,Chen Zhengming and Li Liming. Associations between season of birth and age both at menarche and at menopause[J]. Chinese Journal of Epidemiology, 2017, 38(7): 877-882 |
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| Authors: | Si Jiahui Meng Ruogu Lyu Jun Guo Yu Bian Zheng Yu Canqing Yang Ling Tan Yunlong Pei Pei Chen Junshi Chen Zhengming Li Liming |
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| Affiliation: | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China,Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China,Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China,Chinese Academy of Medical Sciences, Beijing 100010, China,Chinese Academy of Medical Sciences, Beijing 100010, China,Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China,Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX1 3QR, UK,Chinese Academy of Medical Sciences, Beijing 100010, China,Chinese Academy of Medical Sciences, Beijing 100010, China,China National Center for Food Safety Risk Assessment, Beijing 100020, China,Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX1 3QR, UK and Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Chinese Academy of Medical Sciences, Beijing 100010, China |
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| Abstract: | Objective To examine the associations between season of birth and factors as age at menarche, age at menopause and reproductive span. Methods A total of 285 186 female from the China Kadoorie Biobank, with complete data on critical variables and had menarche at 9-18 years old, were included. A total of 132 373 female with natural menopause were included for the analysis on age at menopause and reproductive span. Multiple linear regression models were used to assess the associations of birth season and the age at menarche, menopause, and reproductive span. Subgroup analyses were performed on birth cohorts and urban/rural residence. Results Compared with the Spring-born (March, April, and May), participants who were born in Summer (June, July, and August), Autumn (September, October, and November), and Winter (December, January, and February) appeared late on both age at menarche and menopause. Multivariable-adjusted coefficients (95%CI) appeared as 0.14 (95%CI:0.13-0.16), 0.26(95%CI:0.24-0.27), 0.10 (95%CI:0.08-0.12) for age at menarche respectively and 0.14 (95%CI:0.08-0.20), 0.18 (95%CI:0.12-0.24), 0.09 (95%CI:0.03-0.16) for age at menopause respectively. No statistically significant association was found between the season of birth and reproductive span. The association was consistent between urban and rural residents and across the birth cohorts. Conclusions female born in spring showed both earlier age on both menarche and menopause, compared to the ones born in other seasons. Our findings suggested that exposures in early life with some degree of seasonal variation might influence the development of female reproductive system. |
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| Keywords: | Birth season Early life Age at menarche Age at menopause Reproductive span |
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