| 培补肝肾复方对1-甲基-4-苯基吡啶离子致多巴胺能神经元损伤的影响 |
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| 引用本文： | 田季雨,陈建宗,陈晓莉,杨浩.培补肝肾复方对1-甲基-4-苯基吡啶离子致多巴胺能神经元损伤的影响[J].现代中西医结合杂志,2003,12(21):2267-2269. |
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| 作者姓名： | 田季雨 陈建宗 陈晓莉 杨浩 |
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| 作者单位： | 1. 中国人民解放军第四军医大学西京医院,陕西,西安,710032
2. 中国人民解放军第四军医大学神经生物研究所,陕西,西安,710014 |
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| 摘 要： | 目的 观察 1-甲基 - 4 -苯基吡啶离子 (MPP+ )对原代培养的新生鼠中脑多巴胺能神经元数目和形态的改变 ,并探讨培补肝肾复方对多巴胺能神经元的保护作用和机制。方法 采用血清药理学的方法 ,观察培补肝肾复方含药血清对MPP+ 损伤多巴胺能神经元细胞存活时间、存活率的影响及细胞形态学的变化。结果 等效剂量培补肝肾中药复方含药血清(灌胃剂量为 3g/kg)可延长MPP+ 损伤多巴胺神经细胞的存活时间 ,提高细胞的存活率。结论培补肝肾复方中药血清对体外培养MPP+ 损伤的多巴胺能神经细胞具有保护作用。
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| 关 键 词： | 培补肝肾复方 多巴胺能神经元 1-甲基-4-苯基吡啶离子 |
| 文章编号： | 1008-8849(2003)21-2267-03 |
| 修稿时间： | 2003年4月21日 |
Effects of compound Peibuganshen on cultured rat dopaminergic neurons injured by 1-methyl-4-phenylpyridinium |
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| TIAN Ji-yu ,CHEN Jian-zong ,CHEN Xiao-li ,YANG Hao.Effects of compound Peibuganshen on cultured rat dopaminergic neurons injured by 1-methyl-4-phenylpyridinium[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2003,12(21):2267-2269. |
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| Authors: | TIAN Ji-yu CHEN Jian-zong CHEN Xiao-li YANG Hao |
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| Institution: | TIAN Ji-yu 1,CHEN Jian-zong 1,CHEN Xiao-li 1,YANG Hao 2 |
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| Abstract: | Objective It is to observe the effects of 1-methyl-4-phenylpyridinium ( MPP +) on amount and form of dopaminergic neurons in primary culture newborn rat and explore the protective function of compound Peibuganshen on dopaminergic neurons and its mechanism. Methods The effects of compound Peibuganshen on the survival time, survival rate and form of dopaminergic neurons cell injured by MPP + were detected with the method of serum pharmacology. Results The equivalent dosage of the serum of compound Peibuganshen improved the survival time and survival rate of dopaminergic neurons cell injured by MPP +. Conclusion The serum of compound Peibuganshen has protective function on dopaminergic neurons cells injured by MPP +. |
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| Keywords: | compound Peibuganshen dopaminergic neurons 1-methyl-4-phenylpyridinium |
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