Comparison of family histories in FTLD subtypes and related tauopathies |
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Authors: | Goldman J S Farmer J M Wood E M Johnson J K Boxer A Neuhaus J Lomen-Hoerth C Wilhelmsen K C Lee V M-Y Grossman M Miller B L |
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Affiliation: | Memory and Aging Center, University of California, San Francisco, CA 94117, USA. jgoldman@memory.ucsf.edu |
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Abstract: | Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks. |
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