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Comparison of family histories in FTLD subtypes and related tauopathies
Authors:Goldman J S  Farmer J M  Wood E M  Johnson J K  Boxer A  Neuhaus J  Lomen-Hoerth C  Wilhelmsen K C  Lee V M-Y  Grossman M  Miller B L
Affiliation:Memory and Aging Center, University of California, San Francisco, CA 94117, USA. jgoldman@memory.ucsf.edu
Abstract:Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.
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