人工肝支持系统治疗慢性重型病毒性肝炎的临床评价

目的：探讨人工肝支持系统（ALSS）治疗慢性重型病毒性肝炎的临床价值。方法：应用ALSS治疗55例（162次）慢性重型肝炎患者，并同时选择常规治疗56例患者作为对照组，每次ALSS治疗前后检测生化和免疫指标。结果：每次ALSS治疗后患者肝功能显著改善，球蛋白降至正常参考值范围；血内毒素含量下降；但肿瘤坏死因子、白介素－2、白介素－2受体，电解质等每次治疗前后无明显；ALSS治疗的并发症主要为皮疹、低血压等，但大多数患者耐受；临床治愈好转率61．8％，明显高于对照组17．9％（P＜0．01）。结论：ALSS是辅助治疗重毒性肝炎的有效方法。

Clinical evaluation of treatment with artificial liver support system in chronic fulminant viral hepatitis

Objective:To evaluate clinically the treatment with artificial liver support system (ALSS) in chronic fulminant viral hepatitis.Methods:Fiftyfive cases (162 episodes) were treated with ALSS,56 cases with convontional treatment as controls.Immunological and biochemical tests were performed before and after treatment with ALSS.Results:It showed that liver function parameters were markedly improved after treatment with ALSS,e.g.,serum globulin returned to normal,serum endotoxin decreased.There were no changes in levels of tumor necrosis factor(TNF),interleukin2(IL2) as well as interleukin2 receptor(IL2R),and blood electrolyte etc.after ALSS treatment.Complications of ALSS included rash,hypotention etc.,but most patients could tolerated well.Clinical curative rate in ALSS group was much higher than in the controls (61 8% vs.17 9%, P <0 01).Conclusions:Our results showed that ALSS treatment in chronic fulminant viral hepatitis could alleviate the organ damage and improve the clinical curetive rate.