| 影响粉末直接压片的中药提取物物理性质研究 |
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| 引用本文： | 李姝琦,冯怡,徐德生,王优杰,付小菊,阮克萍. 影响粉末直接压片的中药提取物物理性质研究[J]. 中国药学杂志, 2010, 45(8): 607-610 |
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| 作者姓名： | 李姝琦 冯怡 徐德生 王优杰 付小菊 阮克萍 |
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| 作者单位： | 上海中医药大学中药现代制剂技术教育部工程研究中心;上海中医药大学附属曙光医院;国际特品有限公司医药技术服务中心(中国); |
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| 基金项目： | 国家教育部博士点专项基金(20060268008); 上海市教委重点学科资助(J50302); 国家科技重大专项(2009ZX09502-009); 上海市科委项目(09DZ2292000) |
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| 摘 要： | 目的 研究中药提取物物理性质对粉末直接压片的影响。方法 应用多元回归分析方法考察了粉末的休止角、压缩度（卡尔指数）、黏聚力、压片压力等参数与片剂抗张强度的相关关系。结果 压缩度、黏聚力及压片时的压力均与片剂的抗张强度呈明显的正相关关系。结论 中药提取物物理性质是影响粉末直接压片的重要物理性质参数，这些物理性质保证在一定的适宜范围内中药提取物方可进行直接压片。
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| 关 键 词： | 中药提取物 直接压片 抗张强度 多元回归分析 |
| 收稿时间： | 2012-01-01; |
Effect of Physical Properties on Direct Compression of Herbal Extracts |
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| LI Shu-qi,FENG Yi,XU De-sheng,WANG You-jie,FU Xiao-ju,RUAN Ke-ping,Shanghai ,China). Effect of Physical Properties on Direct Compression of Herbal Extracts[J]. Chinese Pharmaceutical Journal, 2010, 45(8): 607-610 |
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| Authors: | LI Shu-qi FENG Yi XU De-sheng WANG You-jie FU Xiao-ju RUAN Ke-ping Shanghai China) |
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| Affiliation: | LI Shu-qi1,FENG Yi1,XU De-sheng2,WANG You-jie1,FU Xiao-ju1,RUAN Ke-ping3(1.Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM,Ministry of Education,Shanghai 201203,China,2.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200213,3.Pharmaceutical Technical Service Center,International Special Product LTD(China),Shanghai 200233,China) |
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| Abstract: | OBJECTIVE To investigate the influence of physical properties of herbal extracts on direct compression.METHODS The influence of angle of repose,carr'index,cohesion and pressure of herbal extracts on tensile strength of formed tablets was investigated by multiple regression analysis.RESULTS The compressibility,cohesion and pressure were positively correlated with tensile strength in measured range.CONCLUSION The direct compression was highly influenced by the physical properties of herbal extracts.These phys... |
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| Keywords: | herbal extracts direct compression tensile strength multiple regression analysis |
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