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Pepsin detection in patients with laryngopharyngeal reflux before and after fundoplication |
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| Authors: | Eelco Wassenaar Nikki Johnston Albert Merati Martin Montenovo Rebecca Petersen Roger Tatum Carlos Pellegrini Brant Oelschlager |
| Affiliation: | (1) Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, 98195 Seattle, WA, USA;(2) Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA;(3) Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA |
| Abstract: | BackgroundSome patients with gastroesophageal reflux disease (GERD) suffer from laryngopharyngeal reflux (LPR). There is no reliable diagnostic test for LPR as there is for GERD. We hypothesized that detection of pepsin (a molecule only made in the stomach) in laryngeal epithelium or sputum should provide evidence for reflux of gastric contents to the larynx, and be diagnostic of LPR. We tested this hypothesis in a prospective study in patients with LPR symptoms undergoing antireflux surgery (ARS). |
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