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| 羊脂油对淫羊藿炮制品提取物中宝藿苷Ⅰ在大鼠体内药动学特征的影响 | |
| 引用本文： | 钱浅,孙娥,樊宏伟,崔莉,谭晓斌,韦英杰,贾晓斌.羊脂油对淫羊藿炮制品提取物中宝藿苷Ⅰ在大鼠体内药动学特征的影响[J].中草药,2012,43(10):1981-1985. |
| 作者姓名： | 钱浅 孙娥 樊宏伟 崔莉 谭晓斌 韦英杰 贾晓斌 |
| 作者单位： | 1. 江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028;江苏大学药学院,江苏镇江212013 2. 江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京,210028 3. 南京医科大学附属南京第一医院临床药理实验室,江苏南京,210006 |
| 基金项目： | 国家自然科学基金资助项目(30572372,30973944);江苏省六大人才高峰资助项目(2009);江苏省中医药科学技术项目(LZ09067) |
| 摘 要： | 目的 研究炮制辅料羊脂油对淫羊藿炮制品提取物中主要活性成分宝藿苷Ⅰ在大鼠体内药动学特征的影响.方法 大鼠分别ig给予相同剂量(15 g/kg)的淫羊藿生品提取液、加热品提取液、羊脂油炙品提取液,HPLC-ESI-MS法测定大鼠宝藿苷Ⅰ血药浓度,经DAS 2.0程序处理数据,比较宝藿苷Ⅰ药动学参数.结果 3种淫羊藿炮制品提取物在血液中的达峰浓度(Cmax)、药时曲线下面积(AUC)等药动学参数大小为油炙品＞加热品＞生品,均具有统计学差异.结论 羊脂油能促进淫羊藿提取物中宝藿苷Ⅰ的口服吸收,提高其生物利用度. |
| 关 键 词： | 淫羊藿提取物 宝藿苷Ⅰ 药动学 羊脂油 生物利用度 |
| 收稿时间： | 2/2/2012 12:00:00 AM |
Effect of suet oil on in vivo pharmacokinetic characteristics of icariside I in extract from processed Epimedii Herba in rats |
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| QIAN Qian,SUN E,FAN Hong-wei,CUI Li,TAN Xiao-bin,WEI Ying-jie and JIA Xiao-bin.Effect of suet oil on in vivo pharmacokinetic characteristics of icariside I in extract from processed Epimedii Herba in rats[J].Chinese Traditional and Herbal Drugs,2012,43(10):1981-1985. | |
| Authors: | QIAN Qian SUN E FAN Hong-wei CUI Li TAN Xiao-bin WEI Ying-jie and JIA Xiao-bin |
| Institution: | 1,2 1.Key Laboratory of New Drug Delivery System of Chinese Materia Medica,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China 2.Department of Pharmaceutics,Jiangsu University,Zhenjiang 212013,China 3.Clinical Pharmacology Laboratory,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China |
| Abstract: | Objective To research the influence of suet oil on in vivo pharmacokinetic characteristics of icariside I in extract from processed Epimedii Herba in rats.Methods The rats were ig administrated with the extract solutions of raw products,heating products,and processed products(15 g/kg),respectively.The plasma drug concentration of icariside I was analyzed by HPLC-ESI-MS.The data were processed by program DAS 2.0 and the pharmacokinetic parameters of icariside I were compared.Results The differences of Cmaxand AUC among three products were statistically significant(processed products > heating products > raw products).Conclusion Suet oil could promote the oral absorption of icariside I in extract from processed Epimedium Herba and increase the bioavailability. |
| Keywords: | extract from processed Epimedii Herba icariside I pharmacokinetics suet oil bioavailability |
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