101株金黄色葡萄球菌的耐药性分析

目的了解住院患者金黄色葡萄球菌感染对常用抗菌药的耐药情况,指导临床合理使用抗菌药物。方法应用Walk Away96SI对2009～2010年临床各科室分离的101株金黄色葡萄球菌的药敏结果进行统计分析。结果分离出的101株金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)占20.79%,青霉素、头孢唑林、苯唑西林、氨苄西林、阿莫西林/克拉维酸100%耐药,利奈唑胺、万古霉素、链阳性菌素复方制剂100%敏感。甲氧西林敏感金黄色葡萄球菌(MSSA)占79.21%,氨苄西林、青霉素耐药率分别为71.25%和75%,利奈唑胺100%敏感。结论金黄色葡萄球菌除对青霉素和氨苄西林表现出高耐药性外,体外抗菌活性均较好,尤其是利奈唑胺耐药率为0,可作为临床用药参考依据。

Drug resistance analysis in 101 strains of staphylococcus aureus

Objective To understand the drug resistance of staphylococcus aureus isolated in our hospital,and to guide the rational use of antibiotics.Methods The drug resistance of 101 strains of staphylococcus aureus isolated in our hospital from 2009 to 2010 were detected by Walk Away 96SI.Results 101 strains of staphylococcus aureus were separated from clinical specimens,20.79% were MRSA.To penicillin,cefazolin,oxacillin,ampicillin,amoxicillin/clavulanic acid,the rate of antibiotic resistance of MRSA was 100%.There was no MRSA strains showing drug resistance to vancomycim and linezolid.The percentage of MSSA was 79.21%.The drug resistance to ampicillin and penicillin was 71.25% and 75%and that to linezolid was 0%.Conclusion Staphylococcus aureus showed high resistance to penicillin and ampicillin,and the drug resistance to other antibiotics was low,especially to linezolid（0）,which could be used as reference for clinical treatment.