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| 血卟啉二甲酯及双乙酰血卟啉二甲酯的制备和鉴定 | |
| 引用本文： | 刘永漋,杨世林,白亦莉,石世芬,吴正贵. 血卟啉二甲酯及双乙酰血卟啉二甲酯的制备和鉴定[J]. 药学学报, 1985, 20(7): 545-547 |
| 作者姓名： | 刘永漋 杨世林 白亦莉 石世芬 吴正贵 |
| 作者单位： | 中国医学科学院药物研究所，扬州生物化学制药厂 北京，扬州 |
| 摘 要： | 血卟啉衍生物(Hematoporphyrin derivative,简称HPD)结合激光诊治肿瘤,是国外近年来发展起来的一种新技术,用于诊断和治疗体表和体腔内的多种癌症,展示了较好的前景。用国产HPD治疗多种癌症亦取得了初步效果。临床上应用的血卟啉衍生物是多种卟啉类化合物的混合物。为了搞清血卟啉衍生物的有效成分,国内外已从HPD中分出了多种 |
| 关 键 词： | 血卟啉二甲酯 双乙酰血卟啉二甲酯 氢谱 碳谱 |
| 收稿时间： | 1984-11-16 |
PREPARATION AND IDENTIFICATION OF HEMATOPORPHYRIN DIMETHYL ESTER AND ITS DIACETYL DERIVATIVE |
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| LIU Yong-Long,YANG Shi-Lin,BAI Yi-Li,SHI Shi-Fen and WU Zheng Gui. PREPARATION AND IDENTIFICATION OF HEMATOPORPHYRIN DIMETHYL ESTER AND ITS DIACETYL DERIVATIVE[J]. Acta pharmaceutica Sinica, 1985, 20(7): 545-547 | |
| Authors: | LIU Yong-Long YANG Shi-Lin BAI Yi-Li SHI Shi-Fen WU Zheng Gui |
| Abstract: | Starting from protoporphyrin a chromatographic pure hematoporphyrin dimethyl ester and its diacetyl derivative were prepared. The purification procedure with countercurrent distribution and column chromatography with alumina oxide and silica gel was described. Both compounds were identified on the basis of their IR, UV, MS, TLC, HPLC and ~1H and ~(13)C NMR spectroscopic analysis. The ~(13)C NMR assignments are given, which seem to be useful for the identification of different porphyrins. |
| Keywords: | Hematoporphyrin dimethyl ester Diacetyl hematoporphyrin dimethyl ester ~1H NMR spectrum ~(13)C NMR spectrum |
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