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Risk factors of cognitive impairment in pediatric epilepsy patients with focal cortical dysplasia |
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| Authors: | Nobusuke Kimura Yukitoshi Takahashi Hideo Shigematsu Katsumi Imai Hiroko Ikeda Hideyuki Ootani Rumiko Takayama Yukiko Mogami Noriko Kimura Koichi Baba Kazumi Matsuda Takayasu Tottori Naotaka Usui Satohiko Kondou Yushi Inoue |
| Affiliation: | National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, NHO, Shizuoka, Japan |
| Abstract: | ObjectiveThe purpose of this study was to identify the risk factors of cognitive impairment in pediatric epilepsy patients with focal cortical dysplasia (FCD).Methods77 patients with histopathologically confirmed FCD were studied. The statistical relationship between cognition levels and clinical factors at presurgical evaluation was analyzed. Cognitive function was evaluated by development quotient or intelligence quotient (DQ-IQ).ResultsAges at seizure onset were younger than 15?years (mean?±?SD; 5.0?±?4.2?years). Mean disease duration was 14.5?±?8.5?years. Mean age at pre-surgical DQ-IQ evaluation was 34.8?±?10.7?years. Mean DQ-IQ was 60.5?±?20.5, and 41 of 77 (53.2%) patients had mental retardation (DQ-IQ?2?=?0.63, p?ConclusionsOur study suggests that seizure characteristics including higher seizure frequency pattern, a history of epileptic spasm, status epilepticus, seizure clustering and early onset of seizure are risk factors of cognitive impairment in FCD patients. |
| Keywords: | Pediatric epilepsy Focal cortical dysplasia Cognitive impairment Risk factors |
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