头颈部髓外浆细胞瘤临床分析

目的:总结头颈部髓外浆细胞瘤(EMP)的临床特征、诊断和治疗经验,提高治疗效果。方法:回顾性分析8例头颈部髓外浆细胞瘤的临床资料。发生于鼻腔3例、上颌窦2例、鼻咽部2例、口咽后壁1例。结果:8例均病理学确诊为浆细胞瘤,全部接受手术治疗,其中4例术后追行放疗。4例无瘤生存者分别已超过1年、5年、10年、12年;3例死亡,其中1例在出院2年后死于局部复发,1例3年后死于多发性骨髓瘤,1例2年后死于心脏病;失访1例。结论:头颈部髓外浆细胞瘤属于低度恶性肿瘤,诊断主要依靠临床表现和病理,手术和放疗是其主要治疗手段。

Clinical analysis of extramedullary plasmacytomas in the head and neck

Objective:To summarize the clinical features and the experiences of diagnosis and treatment of extramedullary plasmacytomas (EMPs), and to enhance the cure rates of EMPs.Method:Clinical data of 8 patients with EMPs in head and neck, who treated in our hospital from Jan. 1990 to Dec. 2004, were reviewed. Of 8 cases, 3 cases with the tumors occurred in nasal cavities, 1 in maxillary sinus, 2 in nasopharynx, 1 in posterior wall of oropharynx.Result:Eight patients who were all pathologic confirmed EMP accepted surgical resections of the tumors, and 4 of 8 cases were boosted radiation therapy post-operation. Four cases were still alive disease-free for more than 1, 5, 10 and 12 years after treatments, respectively. One died of local recurrence in 2 years, 1 died of multiple myeloma in 3 year, and 1 died of heart attack in 2 years after treatments, respectively. One lost follow-up.Conclusion:EMPs in head and neck are low potential malignancy tumors. The diagnosis of EMPs mainly depends on clinical manifestations and pathological results. Surgery and radiation therapy are the main treatments for EMPs in head and neck.