| 慢性荨麻疹患者血清白细胞介素-18和白细胞介素-10的检测 |
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| 引用本文： | 李立红,董萍云,刘晓松. 慢性荨麻疹患者血清白细胞介素-18和白细胞介素-10的检测[J]. 中国皮肤性病学杂志, 2007, 21(1): 28-28,31 |
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| 作者姓名： | 李立红 董萍云 刘晓松 |
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| 作者单位： | 河北医科大学第二医院皮肤科,河北,石家庄,050000 |
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| 摘 要： | 目的检测慢性荨麻疹患者Th1型细胞因子IL-18和Th2型细胞因子IL-10血清水平,进一步探讨慢性荨麻疹免疫学发病机制。方法采用ELISA法检测30例皮肤变应原试验阳性的荨麻疹患者及20例正常人外周血血清IL-18和IL-10水平。结果慢性荨麻疹患者IL-18水平低于正常人(P<0.05),IL-10水平高于正常人(P<0.05)。结论慢性荨麻疹的发病与机体免疫有关,Th1/Th2失衡在慢性荨麻疹的发病中具有重要作用。
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| 关 键 词： | 慢性荨麻疹 IL-18 IL-10 |
| 文章编号： | 1001-7089（2007）01-0028-02 |
| 收稿时间： | 2005-12-23 |
| 修稿时间： | 2005-12-232006-03-27 |
Detection of IL-18 and IL-10 in Sera of Patients with Chronic Urticaria |
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| LI Li-hong,DONG Ping-yun,LIU Xiao-song. Detection of IL-18 and IL-10 in Sera of Patients with Chronic Urticaria[J]. The Chinese Journal of Dermatovenereology, 2007, 21(1): 28-28,31 |
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| Authors: | LI Li-hong DONG Ping-yun LIU Xiao-song |
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| Affiliation: | Department of Dermatology,the Second Hospital of Hebei Medical University ,Shijiazhuang 050000, China |
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| Abstract: | ObjectiveTo examine serum level of Th1 cytokine IL-18 and Th2 cytokine IL-10 in patients with chronic urticaria and to further discuss the immune pathogenesis of chronic urticaria.MethodsIL-18 and IL-10 serum concentration of 30 cases of allergen positive patients with chronic urticaria and 20 cases of healthy controls were detected by ELISA method.ResultsIL-18 serum concentrations were lower in patients with chronic urticaria than that in normal controls (P<0.05).There was higher express ion of IL-10 in patients than that in controls (P<0.05).ConclusionIt indicates that chronic urticaria has relation with human immune.Th1 and Th2 misbalance perhaps plays an important role in chronic urticaria. |
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| Keywords: | IL-18 IL-10 |
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