原发性肝癌患者乙型及丙型肝炎病毒感染的检测

目的　调查原发性肝癌患者乙型及丙型肝炎病毒感染情况。　方法　采用免疫组织化学 SP法检测15 7例原发性肝癌患者乙型肝炎病毒 (HBV)及丙型肝炎病毒 (HCV)感染情况 ,每例患者均有血清学检测资料 ,另取 30例良性肝病组织作对照 ,所有数据用卡方检验。　结果　 15 7例原发性肝癌患者中 HBV感染阳性率为31.8% (5 0 / 15 7) ,HCV感染阳性率为 5 1.0 % (80 / 15 7) ,其中 10 7例原发性肝细胞癌 HBV、HCV感染阳性率分别为39.3% (42 / 10 7) ,4 5 .8% (49/ 10 7) ,5 0例胆管细胞癌 HBV、 HCV感染阳性率分别为 16 .0 % (8/ 5 0 ) ,6 2 .0 %(31/ 5 0 ) ,原发性肝细胞癌、胆管细胞癌 HBV、HCV重叠感染率分别为 2 7.1% (2 9/ 10 7) ,14 .0 % (7/ 5 0 ) ,良性肝病组HBV、HCV感染阳性率分别为 16 .7% (5 / 30 ) ,30 .0 % (9/ 30 )。原发性肝细胞癌 HBV感染、胆管细胞癌 HCV感染率高于良性肝病组 ,差异均有显著性 (P<0 .0 5 )。原发性肝细胞癌 HBV、HCV血清学检测阳性率分别为 87.8%(94 / 10 7) ,13.1% (14 / 10 7) ,胆管细胞癌 HBV、HCV血清学检测阳性率分别为 6 8.0 % (34/ 5 0 ) ,16 .0 % (8/ 5 0 )。　结论　原发性肝癌与 HBV、HCV的感染有密切关系

Detection of HBV and HCV Infection in Patients with Primary Liver Cancer

Objective\ To study the infective rate of B type hepatitis virus(HBV) and C type hepatitis virus(HCV) in 157 patients with primary liver cancer in Fujian province.\ Methods\ SP immunohistochemical method was used to detect the HBV and HCV infection of 157 patients with primary liver cancer, 30 patients of benign liver disease to be control.\ Results\ 107 cases of primary hepatocellular carcinoma the rate of HBV and HCV gene expression were 39 3%(42/107) and 45 8%(49/107), respectively; 50 cases of cholangiocellular carcinoma the rate of HBV and HCV expression were 16 0%(8/50) and 62 0%(31/50), respectively. The rate of HBV and HCV infection of benign liver disease group were 16 7%(5/30) and 30 0%(9/30).\ Both the infection rate of HBV of primary hepatocellular carcinoma and the infection rate of HCV of cholangiocellular carcinoma were higher than the benign liver disease group(P<0 05).\ The serum antibodies positive rate of HBV and HCV in primary hepatocellular carcinoma were 87 8%(94/107) and 13 1%(14/107), respectively.\ The serum positive rate of HBV and HCV in cholangiocellular carcinoma were 68 0%(34/50) and 16 0%(8/50), respectively.\ Conclusion\ Primary liver cancer is closely related to the infection of HBV and HCV.