Comparison of larvicidal, adulticidal and acaricidal activity of two geometrical butylidenephthalide isomers |
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Authors: | Tsukamoto Toshihiko Nakatani Saki Yoshioka Yoshiaki Sakai Naomi Horibe Isao Ishikawa Yukio Miyazawa Mitsuo |
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Affiliation: | Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Higashiosaka, Osaka, Japan. |
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Abstract: | Insecticidal and acaricidal activities of two geometrical isomers, (E)- and (Z)-butylidenephthalide isolated from Angelica acutiloba, against larvae and adults of fruit fly (Drosophila melanogaster), cat fleas (Ctenocephalides felis) and house dust mites (Dermatophagoides farinae and Tyrophagus putrescentiae) were investigated and compared with that of positive controls. (E)- and (Z)-Butylidenephthalide exhibited 50% lethal concentration (LC50) values of 2.07 and 0.94 micromol/ml of diet concentration against larvae of D. melanogaster, respectively. This indicated that two isomers of butylidenephthalide have geometrical stereoselectivity for larvicidal effect. Even though both (E)- and (Z)-butylidenephthalide also showed potent adulticidal and acaricidal activity against adults of D. melanogaster and two mites, there was no significant difference between two isomers. Insecticidal activity of both (E)- and (Z)-butylidenephthalide toward adults of C. felis was not detected even at the maximum concentration of 200 microg/cm2. |
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