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| ABCA1在胆固醇逆转运中作用的研究进展 | |
| 引用本文： | 张晓菲,谭晓华,杨磊. ABCA1在胆固醇逆转运中作用的研究进展[J]. 杭州医学高等专科学校学报, 2010, 0(3): 214-217 |
| 作者姓名： | 张晓菲 谭晓华 杨磊 |
| 作者单位： | [1]石河子大学新疆地方与民族高发病省部共建教育部重点实验室,新疆石河子832002 [2]杭州师范大学医药卫生管理学院,浙江杭州310036 |
| 基金项目： | 国家自然科学基金项目（30860241） |
| 摘 要： | ATP结合盒转运蛋白A1（ATP-binding cassette transporter A1,ABCA1）是一种以ATP为能源进行物质转运的膜蛋白,胆固醇、磷脂等脂类物质是ABCA1的主要转运底物,胆固醇负荷、cAMP、PPAR等信号在调节ABCA1表达中有重要影响。ABCA1在胆固醇逆转运（reverse cholesterol transport,RCT）过程中与载脂蛋白结合参与高密度脂蛋白（high density lipoprotein,HDL）的形成,是RCT中的第一步也是关键的一步,也是该领域中研究的热点。 |
| 关 键 词： | ATP结合盒转运蛋白 载脂蛋白 高密度脂蛋白 胆固醇逆转运 |
The Research Progress of ABCA1 in Cholesterol Reverse Transport |
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| ZHANG Xiao-fei,TAN Xiao-hua,YANG Lei. The Research Progress of ABCA1 in Cholesterol Reverse Transport[J]. Journal of Hangzhou Medical College, 2010, 0(3): 214-217 | |
| Authors: | ZHANG Xiao-fei TAN Xiao-hua YANG Lei |
| Affiliation: | 1.Laboratory of Xinjiang Endemic and Ethnic Disease,College of Medicine,Shihezi University,Shihezi,Xinjiang,832000 China;2.The College of Medicine and Health Management,Hangzhou Normal University,Hangzhou,Zhejiang,310036,China) |
| Abstract: | ATP-binding cassette transporter A1（ABCA1） is a membrane protein with ATP energy.Cholesterol,phospholipids and other lipids are major transit substrates of ABCA1.Cholesterol loading,cAMP,PPAR expression and other signals have important influences in the regulation of ABCA1 expression.ABCA1 binds with apolipoprotein and involves in the formation of high-density lipoprotein in reverse cholesterol transport（RCT）,which is the first and key step in RCT and is the hotspot of the research in this field. |
| Keywords: | ATP-binding cassette transporter apolipoprotein high density lipoprotein cholesterol reverse transport |
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