| 乳腺浸润性导管癌腋窝淋巴结转移与趋化因子受体CCR6/CCL20表达的关系 |
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| 引用本文： | 马向涛,余力伟,付静. 乳腺浸润性导管癌腋窝淋巴结转移与趋化因子受体CCR6/CCL20表达的关系[J]. 中华实验外科杂志, 2008, 25(5) |
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| 作者姓名： | 马向涛 余力伟 付静 |
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| 作者单位： | 1. 北京海淀医院外科,100080
2. 北京海淀医院病理科,100080 |
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| 摘 要： | 目的 观察CCR6/CCL20在乳腺浸润性导管癌腋窝淋巴结转移中的作用.方法 应用Western blot检测55例乳腺浸润性导管癌患者标本中肿瘤组织、邻近正常组织以及淋巴结转移组织中CCR6/CCL20通路成员的表达情况.结果 乳腺癌组织中CCR6/CCL20表达水平明显增高分别为正常组织的3.6、2.1倍(P＜0.05,P＞0.05);CCR6表达水平与腋窝淋巴结转移相关(P＜0.05).结论 趋化因子受体CCR6/CCL20表达可能在乳腺癌腋窝淋巴结转移过程中起重要作用.
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| 关 键 词： | 乳腺癌 趋化因子 转移 |
Expression of chemokine receptor CCR6/CCL20 and its correlation with lymph node metastasis in human invasive ductal carcinoma |
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| MA Xiang-tao,YU Li-Wei,FU Jing. Expression of chemokine receptor CCR6/CCL20 and its correlation with lymph node metastasis in human invasive ductal carcinoma[J]. Chinese Journal of Experimental Surgery, 2008, 25(5) |
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| Authors: | MA Xiang-tao YU Li-Wei FU Jing |
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| Abstract: | Objective To investigate the potential role of CCR6/CCL20 in axillary node metastasis of breast invasive ductal carcinoma.Methods Tissue samples were collected from 55 patients with breast invasive ductal carcinoma representing various clinicopathological parameters.Western blot analysis was used to detect the expression of CCR6/CCL20.Results CCR6/CCL20 protein level was increased in breast cancer as compared with adjacent normal tissue,with the median value being 3.6 and 2.1-fold respectively (P＜0.05 ,P＞0.05 ).It was found that overexpression of CCR6 was related to lymph node involvement in breast cancer (P＜0.05 ).Conclusion Overexpression of CCR6/CCL20 may play an important role in axillary node metastasis of breast carcinoma. |
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| Keywords: | Breast careionoma Chemokine Metastasis |
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