| 卵巢低反应患者大剂量超排卵的助孕结局 |
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| 引用本文： | 肖红梅,卢光琇. 卵巢低反应患者大剂量超排卵的助孕结局[J]. 生殖医学杂志, 2008, 17(6) |
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| 作者姓名： | 肖红梅 卢光琇 |
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| 作者单位： | 中南大学湘雅医学院生殖与干细胞研究所,中信湘雅生殖与遗传专科医院,长沙,410078 |
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| 摘 要： | 在辅助生殖助孕中通常采用控制性卵巢刺激(controlled ovarian hyperstimulation, COS),以获得适当数量的卵子用于体外受精,既希望获得理想的辅助生殖助孕成功率,又能降低卵巢过度刺激并发症.COS中约有9%~24%[1,2]的卵巢低反应发生率.卵巢低反应者获得有效卵子数少、可移植胚胎数少或无胚胎移植、取消治疗周期率高,累计成功率更低等,导致较差的治疗结局,是辅助生殖助孕中面临的棘手问题.针对卵巢低反应者,大多数辅助生殖中心仍会采用增加促性腺激素(Gn)的起始和(或)总用量以期获得提高助孕结局的目的.而大剂量Gn是否为改善低反应患者助孕结局的有效策略却仍存在争议.
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| 关 键 词： | 卵巢低反应 大剂量促性腺激素 助孕结局 |
In vitro fertilization outcome used high-dose gonadotropin stimulation in poor responders |
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| XIAO Hong-mei,LU Guang-xiu. In vitro fertilization outcome used high-dose gonadotropin stimulation in poor responders[J]. Journal of Reproductive Medicine, 2008, 17(6) |
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| Authors: | XIAO Hong-mei LU Guang-xiu |
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| Affiliation: | XIAO Hong-mei,LU Guang-xiu Reproductive , Stem Cell Engineering Institute,Xiangya Medical School of Central South University,Reproductive , Genetic Hospital of Citic-Xiangya,Changsha 410078 |
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| Abstract: | Poor response is frequent occurrence in controlled ovarian hyperstimulation among patients undergoing IVF treatment.The poor responders have lower pregnancy rates compared with normal responders.Almost all randomized controlled trials showed that high FSH dose improved IVF outcome of poor responders in previous cycle.But,most of the retrospective studies concluded that high FSH dose did not support it.There is still different conclutions.During current practice,the most widely used initial dose for poor res... |
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| Keywords: | Poor ovarian response High gonadotrophin dose Outcome of assisted conception |
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