桔贝合剂在小儿肺炎临床辅助治疗中的应用研究

目的：研究桔贝合剂在小儿肺炎临床辅助治疗中的临床疗效,为小儿肺炎的临床治疗积累经验,并且为临床合理安全用药提供依据。方法：选取本院2011年12月-2013年6月收治的108例小儿肺炎患者作为研究对象,按照随机数字表法将其分为对照组和观察组各54例,对照组给予常规应用利巴韦林注射液静脉滴注进行抗感染治疗,10 mg/（kg·d）,观察组在对照组的基础上加用桔贝合剂,小于3岁的患儿,5 mL/次,3次/d;大于3岁的患儿,10 mL次,3次/d。治疗10 d后,比较两组患儿的临床疗效、临床病理生理参数（退热时间、咳嗽停止时间、湿啰音消失时间、X线恢复正常时间）和不良反应发生情况。结果：治疗10 d后,观察组的总有效率为94.44%,明显高于对照组的61.11%,差异有统计学意义（字2=28.75,P=0.007）,且观察组的退热时间、咳嗽停止时间、湿啰音消失时间、X线恢复正常时间均明显低于对照组,差异均有统计学意义（P〈0.05）,观察组不良反应发生率为5.56%,对照组为3.70%,比较差异无统计学意义（字2=0.86,P=0.261）。结论：对于小儿肺炎患者,可以使用桔贝合剂进行辅助治疗,具有较高临床疗效的同时,安全性也比较高,值得在临床上推广应用。

Study on the Application of Jubei Mixture in Clinical Adjuvant Therapy of Infantile Pneumonia

Objective：To observe the clinical effect of Jubei mixture on clinical adjuvant therapy of infantile pneumonia,to accumulate experience for the clinical treatment of infantile pneumonia,and to provide the basis for clinical medication.Method：A total of 108 patients with infantile pneumonia from December 2011 to June 2013 in our hospital were selected as research objects,they were randomly divided into the observation group and the control group,54 cases in each group.The control group was given routine application of Ribavirin Injection intravenous antibiotic therapy,10 mg/（kg·d）.The observation group was treated with Jubei mixture on the basis of the control group,3 years old,5 mL/time,3 times/days;3 years old,10 mL/time,3 times/days.After treatment with 10 days,the clinical effect,clinical pathological and physiological parameters（abatement of fever time,cough stopping time,extinction time of moist rales,X-ray returned to normal time）and the incidence of adverse reactions of two groups were observed and compared.Result：The total effective rate of the observation group was 94.44%,it was significantly higher than the 61.11% of control group,the difference was statistically significant（χ2=28.75,P=0.007）,and defervescence time,cough stopping time,wet rales disappearance time,X-ray recovery time of the observation group were significantly lower than those in the control group,the differences were statistically significant（P0.05）,the incidence of adverse reaction in the observation group was 5.56%,the control group was 3.70%,there was no significant statistical difference（χ2=0.86,P=0.261）.Conclusion：For patients with infantile pneumonia,the clinical effect of Jubei mixture on clinical adjuvant therapy is good and safety,worthy of clinical application.