原发性阴道恶性黑色素瘤25例临床分析

探讨病灶大小和不同治疗后手段对原发性阴道恶性黑色素瘤预后的影响。方法对我院１９６４年１２月至１９９７年１０月,收治的２５例原发性阴道恶性黑色素瘤患者的临床资料进行回顾性分析。结论原发性阴道恶性黑色素瘤预后差,但如早期诊断并采用以手术为主的综合治疗,有可能改善预后。

Clinical analysis of 25 cases of primary vaginal malignant melanoma

OBJECTIVE: To investigate the influence of tumor size and different treatment method on the prognosis of primary vaginal malignant melanoma. METHOD: The clinical data of 25 patients with primary malignant melanoma of the vagina admitted to our hospital from Dec. 1964 to Oct. 1997 were analysed retrospectively. RESULTS: The overall 2-year and 5-year survival rate were 21.4% and 5.4%, respectively. The mean survival time for patients with tumor diameter < or = 2 cm was 27.7 months and for patients with tumor > 2 cm, 9.7 months (P < 0.05). The mean survival time was 19.5 months for the 17 cases treated with surgery and 8.3 months for another 8 cases who did not received surgery (P < 0.05). Multi-variate Cox regression with tumor size, surgical treatment, chemotherapy and immunotherapy also showed that tumor diameter and surgery were significant variables statistically for survival time (both P < 0.05). CONCLUSION: The prognosis of the primary malignant melanoma of vagina is poor and can be improved if the disease could be diagnosed early and combined modality therapy with emphasis on surgery be given.