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| Peutz-Jeghers综合征中Brg1蛋白的表达及临床意义 | |
| 引用本文： | 刘金霞,周平,胡志民,赵晓,时凤敏,林艳华,毛高平. Peutz-Jeghers综合征中Brg1蛋白的表达及临床意义[J]. 山东医药, 2011, 51(13) |
| 作者姓名： | 刘金霞 周平 胡志民 赵晓 时凤敏 林艳华 毛高平 |
| 作者单位： | 1. 河北北方学院,河北张家口,075000 2. 中国人民解放军空军总医院 3. 郑州大学第二附属医院 |
| 基金项目： | 全军十一五面上课题资助项目 |
| 摘 要： | 目的 探讨Peutz-Jeghers综合征(PJS)中Brg1蛋白的表达及其在PJS息肉发展过程中的作用.方法 应用免疫组化法检测Brg1蛋白在72例PJS息肉组织、12例正常小肠黏膜组织、30例小肠癌组织中的表达,并探讨其与PJS息肉发生、发展及癌变的关系.结果 Brg1蛋白在小肠癌组中的阳性表达率为76.67%,PJS息肉组织为54.17%,正常小肠黏膜组织为16.67%;PJS息肉组和正常小肠黏膜组Brg1蛋白阳性表达差异有统计学意义(P＜0.05);PJS息肉组和小肠癌组Brg1蛋白阳性表达差异有统计学意义(P＜0.05).结论 Brg1蛋白在小肠癌组织中存在过高表达,在PJS息肉组织中存在高表达,且可能是PJS息肉癌变的关键因子之一. |
| 关 键 词： | Peutz-Jeghers综合征 肠肿瘤 Brg1蛋白 免疫组织化学 |
Brg1 protein expression and significance in Peutz-Jeghers syndrome |
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| LIU Jin-xia,ZHOU Ping,HU Zhi-min,ZHAO Xiao,SHI Feng-min,LIN Yan-hua,MAO Gao-ping. Brg1 protein expression and significance in Peutz-Jeghers syndrome[J]. Shandong Medical Journal, 2011, 51(13) | |
| Authors: | LIU Jin-xia ZHOU Ping HU Zhi-min ZHAO Xiao SHI Feng-min LIN Yan-hua MAO Gao-ping |
| Affiliation: | LIU Jin-xia1,ZHOU Ping,HU Zhi-min,ZHAO Xiao,SHI Feng-min,LIN Yan-hua,MAO Gao-ping(1 Hebei North University,Zhangjiakou 075000,P.R.China) |
| Abstract: | Objective To investigate the expression of Brg1 protein in Peutz-Jeghers syndrome,and to study its relation with polyps development.Methods The expressions of Brg1 protein were detected by immunohistochemical streptavidin-perosidase in 72 cases of Peutz-Jeghers,30 cases of cancer and 12 cases of normal tissue.The role of Brg1 protein in Peutz-Jeghers development and prognosis was analyzed.Results In 30 cases of cancer,76.67% of Brg1 protein expression were detected,which was higher than that in PJS tissue 5... |
| Keywords: | Peutz-Jeghers syndrome intestinal neoplasms Brg1 protein immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |