胆石形成基本因素和条件研究

通过扫描电镜和能谱仪同步检测胆囊粘膜、胆石和鲕石的超微结构、金属元素及其氧化物,观察胆石核心的细菌及胆囊收缩素对异形胆囊的收缩效应,探索肝胆功能、肝胆疾病和胆石症的关系。综合研究结果提出:胆石形成的启动因素是肝胆系统的感染与炎症;胆石形成的基本条件是肝胆系统整合和自稳态生理调节的紊乱;胆石结构形成是胆道内胆汁理化力学作用的结果:"肝胆同治"是胆石症的防治原则。

A Research on the Fundamental Factors and Conditions of Gallstone Formation

The authors applied scanning electron microscope with synchronization of EDAX to detect the ultrastructure of gallbladder mucosa,metallic elements and their oxides,to observe the bacteria of the core of the gallstone;applied cholecystokinin to observe the effects of abnormal gallbladder contraction on stone formation;applied biochemical,immunological criteria to determine the association between liver and gallbladder diseases arid gallstone;applied Scanning electron micro- scope to compare the analysis of mechanical structure of ooides and gallstone. According to the results of research,the authors conclude:(1)The basic condition of the formation of the gallstone was the disturbance of physiological reaction of"integration"and"homeostasis"of liver-biliary system.(2)The essential factor of the formation of gallstone was the infection of liver-biliary system.(3)The formation of the gallstone structure was caused by changed physical and chemical mechanics of bite.(4)The synchronization treatment of liver-biliary was the principle of preventing and treating gallstone.