谷胱甘肽转移酶M1基因缺失与苯白血病的相关性分析

目的 探讨苯接触工人谷胱甘肽转移酶M1（GSTμ）基因缺失与苯白血病发病的相关性。方法 采用1：1配比的病例－对照研究和多因素条件Logistic回归分析。结果 GSTμ基因缺失者患苯白血病的危险性为GSTμ基因携带者的3．6倍，提示GSTμ基因缺失是苯白血病发病的危险因素。单因素条件Logistic回归分析显示，作用显著的因素依次是GSTμ基因缺失、GSTμ亚型酶活力、接苯工龄、GST总酶活力、吸烟总量和车间空气中苯的平均浓度。经多因素条件Logistic回归分析后，按相对危险度（OR）大小排列，依次是GSTμ基因缺失、接苯工龄和GSTμ亚型酶活力。结论 GSTμ基因缺失在苯白血病的发生过程中起重要作用，可作为探讨苯白血病人群易感性和发现高危人群的效应标志物。

Study on the relationship between glutathione S transferase μ gene deletion and leukemia in workers exposed to benzene

OBJECTIVE: To study the relationship between glutathione S transferase M1(GST mu) gene deletion and leukemia in workers exposed to benzene. METHODS: A matched population-based case-control survey with multivariate Logistic regression analysis was conducted in this study. RESULTS: In the population of 34 patients and their matched controls, the absence of the GST mu genotype conferred odds ratio of 3.6. It suggested that GST mu was an important determinant of heterogeneity in individual susceptibility to leukemia associated with exposure to benzene. The single-variance analysis indicated that these markedly significant factors were GST mu gene deletion, GST mu isoenzyme activity, duration of exposure, GST isoenzyme activity, smoking quantity and average concentration of benzene in workshop air. The multivariate analysis indicated that these markedly significant factors were GST mu gene deletion, duration of exposure to benzene and GST mu isoenzyme activity. CONCLUSION: GST mu gene deletion may be associated with increased risk of leukemia in workers exposed to benzene and is one of genetically determined factors.