Synthesis and characterization of the Zn(II) and Cu(II) piperidinyl isoeuxanthone complexes: DNA-binding and cytotoxic activity |
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Authors: | Hui-Fang Wang Rui Shen Ning Tang |
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Affiliation: | aCollege of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, South Tianshui Road No. 222, Lanzhou 730000, PR China;bCollege of Pharmacy Nankai University, Tianjin 300071, PR China |
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Abstract: | Two new complexes ZnL2·2H2O (1) and CuL2·2H2O (2) (HL = 1-hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone) have been synthesized and characterized. Their interactions with calf thymus DNA (ct DNA) were investigated by absorption spectroscopy, fluorescence spectroscopy, ethidium bromide (EB) displacement experiments, circular dichroism spectroscopy and viscosity measurements. Experimental results suggested that there were intercalative interactions of the complexes with DNA. The binding affinity of complex 2 was higher than that of 1. In addition, the cytotoxic effects of both complexes were evaluated with lung adenocarcinoma (GLC-82), esophagus squamous cancer (ECA109) and human gastric cancer (SGC7901) cells using MTT assay. Both were potent exhibiting significant cytotoxicity in vitro. |
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Keywords: | 1-Hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone Zn(II) complex Cu(II) complex DNA-binding Intercalative mode Cytotoxic activity |
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