低分子肝素治疗重度子痫前期患者外周血vWF、AT的变化

目的探讨低分子肝素能否改变重度子痫前期患者血浆中vWF含量,AT的活性水平,为低分子肝素用于重度子痫前期的治疗提供新的理论基础。方法选择2010年3月1日～2010年11月30日在天津医科大学宝坻临床学院、天津医科大学总医院分娩的重度子痫前期病人39例为研究组。根据入院顺序随机分成2组,传统治疗组20人,给予传统常规的治疗。低分子肝素治疗组19人,在传统常规治疗的基础上给予低分子肝素钙0.4m1,每天一次,皮下注射,两组分别于入院时及治疗3～5天后抽取孕妇静脉血,检测血浆vWF：Ag和AT：A及常规凝血试验。结果两组重度子痫前期患者治疗前血浆中vWF：Ag与同期对照组比较明显升高,而AT：A与同期对照组比较明显减少,低分子肝素治疗后血浆中vWF：Ag与治疗前比较明显降低,而AT：A与治疗前比较明显增高,传统方法治疗后血浆vWF：Ag和AT：A与治疗前比较差异无统计学意义。结论低分子肝素结合传统疗法治疗重度子痫前期患者,可改变患者血浆中vWF含量,AT的活性水平。

The Changes of vWF,AT in low molecular weight heparin used in severe pre-eclampsia patients

Objective:Evaluate the treatment of severe pre-eclampsia with the low molecular weight heparin.By testing the changes of vWF and AT:A between before and after treatment to explore the affection of the low molecular weight heparin,in order to provide a new theoretical basis.Methods: Choose severe pre-eclampsia pregnant women 39.Dividing into 2groups: One group accept the treatment of LMWH n=19(By the base of tradition treatment give the patients moreover LMWH 0.4ml per day);the other one accept the tradition treatment n=20.Choose another 29 normal pregnancy as the control group.Gather the vein blood from antetheca prior(before and after the treatment),detect the vWF and AT.Results: The level of vWF in pre-eclampsia is higher than normal group and the level of AT is lower.The level of vWF after using LMWH is lower than before treatment,and the AT is higher.There no difference betweenthe tradition treatment.Conclusion: The increased of vWF in pre-eclampsia indicate the patients have endothelial injury and dysfunction,this lead the development of disease.The reduced of AT indicate that the patients break the balance of the coagulation-anticoagulation system.