Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumours |
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Authors: | Kazuto Yamada Takaaki Tanaka Masahiko Mori Airo Tsubura Sotokichi Morii Mikio Tsubone Chiaki Ando Jo Hilgers |
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Institution: | (1) Department of Oral Surgery, Asahi University School of Dentistry, 501-02 Hozumi Gifu, Japan;(2) Department of Pathology, Kansai Medical University, 570 Moriguchi, Osaka, Japan;(3) Laboratory of Clinical Pathology, Ohgaki Municipal Hospital, 503 Ohgaki, Gifu, Japan;(4) Department of Obstetrics and Gynecology, Academisch Ziekenhuis Vrije Universiteit De Boelelaan, 1117 Amsterdam, The Netherlands |
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Abstract: | Summary MAM-3 and MAM-6 antigens of human milk fat globule membrane were detected immunohistochemically in 93 cases of salivary gland tumours as well as in normal glands. The antigens were visualized in 10% formalin-fixed paraffin sections. MAM-3 (MoAbs 115G3, 67D11) antigen was distributed in intercalated and striated duct cells of the normal salivary glands, and in luminal tumour cells and squamous metaplastic cells of pleomorphic adenomas. In pleomorphic adenomas the frequency of positive staining with MoAb 67D11 (54/67; 80.6%) was higher than that with MoAb 115G3 (36/67; 53.7%). MAM-6 (MoAbs 115D8, 115F5) antigen was expressed in luminal and lateral borders of serous acinar cells and ductal of the normal glands, and also in luminal borders of tubulo-ductal and glandular structures of salivary gland tumours. Ductal basal cells were characterized by existence of positive staining for MAM-6 antigen, in adenolymphomas MAM-6 antigen was restricted to the basal tumour cells. Some mucous cells of mucoepidermoid tumours were stained specifically with MoAb 115G3, and epidermoid cells of mucoepidermoid carcinomas manifested MAM-6 antigen staining. Immunohistochemical localization of MAM-6 antigen resembled that of epithelial membrane antigen (EMA) detected with MoAb. |
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Keywords: | MAM-3 and MAM-6 Antigens Human salivary gland tumour Immunohistochemistry |
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