诱导多潜能干细胞治疗脊髓损伤的研究现状与进展

脊髓损伤是困扰医学界的难题。目前临床上的治疗方法效果均不理想。近20年来,干细胞技术飞速发展,在神经疾病和神经损伤的动物模型中应用胚胎和成体干细胞,取得了肯定的结果。在细胞水平上为治疗神经损伤提供了新的前景。但是由于技术和伦理方面的问题,获得可以应用于人类的合适的细胞资源仍有许多困难。最近诱导多功能干细胞的发现,为自体同源移植治疗脊髓损伤提供了新方法。本文将以此为出发点,评估诱导多潜能干细胞向神经细胞分化的能力,以及在这一领域中的最新进展。

Current situation and progression of induced pluripotent stem cells in treating spinal cord injury

Spinal cord injury is a difficult medical problem and current therapeutic methods could not obtain satisfactory results. Recent 20 years,stem cell technology developed rapidly,embryonic stem cells and adult stem cells were used for treating neurological disease and nerve injury of animal models and the clinical results were confirmed. It provided a new prospect for the treatment of nerve injury at the cellular level. However,due to technical and ethical problems,it is difficult to obtain the appropriate cells that can be applied to the human being. Recently,induced pluripotent stem cells were developed as a new method for the treatment of spinal cord injuries by the autologous transplantation. Starting from this work,the purpose of this review is to assess the differentiate ability of induced pluripotent stem cells into neurocyte and review the latest developments in this area.