| 冠心病患者血浆中抗热休克蛋白70抗体表达水平的研究 |
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| 引用本文： | 杨杪,谭皓,陈永文,王峰,何美安,蒋长征,陈胜,邬堂春.冠心病患者血浆中抗热休克蛋白70抗体表达水平的研究[J].劳动医学,2004,21(2):139-140,148. |
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| 作者姓名： | 杨杪 谭皓 陈永文 王峰 何美安 蒋长征 陈胜 邬堂春 |
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| 作者单位： | 华中科技大学同济医学院职业医学研究所 湖北武汉430030
(杨杪，谭皓，陈永文，王峰，何美安，蒋长征，陈胜)，华中科技大学同济医学院职业医学研究所 湖北武汉430030(邬堂春) |
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| 基金项目： | 国家自然科学基金资助项目 (编号 :30 2 0 0 2 2 7) |
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| 摘 要： | 目的 ]检测冠心病患者血浆中抗热休克蛋白 70 (HSP70 )抗体水平与正常人有无差异 ,并探讨其与冠心病发生发展之间的关系。 方法 ]采用Western ELISA方法检测 192例冠心病患者中抗HSP70抗体水平 ,并以 192例无冠心病的个体作为对照。结果 ] 192例冠心病患者中抗HSP70抗体阳性 7例 ,对照组 5例 ,病例组抗体阳性率与对照组之间差异无显著性 (P >0 .0 5 )。 结论 ]本研究未发现抗HSP70抗体与冠心病的发生发展有联系 ,抗HSP70抗体在冠心病发病过程中的作用有待于进一步探讨。
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| 关 键 词： | 冠心病 血浆 抗热休克蛋白70 抗体表达 HSP70 CHD 血管性疾病 |
| 文章编号： | 1006-3617(2004)02-0139-03 |
Levels of Plasma Antibodies to Heat-shock Protein 70 in Patients with Coronary Heart Disease |
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| YANG Miao,TAN Hao,CHEN Yong-wen,WANG Feng,HE Mei-an,JIANG Chang-zheng,CHEN Sheng,WU Tang-chun.Levels of Plasma Antibodies to Heat-shock Protein 70 in Patients with Coronary Heart Disease[J].Journal of Labour Medicine,2004,21(2):139-140,148. |
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| Authors: | YANG Miao TAN Hao CHEN Yong-wen WANG Feng HE Mei-an JIANG Chang-zheng CHEN Sheng WU Tang-chun |
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| Abstract: | To examine the level of plasma antibodies to heat-shock protein 70(HSP70) and evaluate their role in the progression of coronary heart disease. Western-ELISA method was used to examine the plasma levels of anti-HSP70 antibodies in 192 patients with coronary heart disease(CHD) and 192 controls. There were 7 positive in patients of the CHD group and 5 in the control group;there was no significant difference in the levels of anti-HSP70 antibodies was found between the two groups. Conclusion] The anti-HSP70 antibodies are not related to the pathogenesis of coronary heart disease,however the role of anti-HSP70 antibodies in the development of coronary heart disease remains to be studied further. |
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| Keywords: | antibodies to heat-shock protein 70(HSP70) coronary heart disease plasma |
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