CD4~+CD25~+FOXP3~+调节性T细胞在结核病发生中的作用研究

目的:探讨CD4+CD25+FOXP3+调节性T细胞在结核病发生中的作用。方法:采用回顾性分析的方法,分析我院收治的60例结核病患者(观察组)和60例健康体检者(对照组)的临床资料。结果:观察组治疗前CD4+CD25+FOXP3+调节性T细胞比例明显高于对照组,治疗2、6个月末观察组患者CD4+CD25+FOXP3+调节性T细胞比例明显降低,观察组CD4+CD25+FOXP3+调节性T细胞比例与CD4+T细胞、CD8+T细胞、IFN-γ和IL-4呈现明显的负相关(P<0.05)。结论:针对CD4+CD25+FOXP3+调节性T细胞在结核病发生机制中的作用,开展从免疫治疗和结核病疫苗设计提供新的作用靶点和诊疗依据,值得临床推广应用。

Study on the role of CD4~+ CD25~+ FOXP3~+ regulatory T cells in-tuberculosis

Objective To determine the role of CD4+ CD25+ FOXP3+ regulatory T cells in tuberculosis. Methods The retrospective analysis is usedin our 60 cases of tuberculosis patients(obeservation group) and 60 cases of healthy (control group) check-up clinical data. Results Before treatment, CD4+ CD25+ FOXP3+ regulatory T cells ratio of the observation group is significantly higher than the control group but significantly redued after treatment on them. The observation group CD4+ CD25+ FOXP3+ regulatory T cells and CD4+ T cells proportion, CD8+ T cells, IFN-γ and IL-4 showed a significant negative correlation(P < 0.05). Conclusion The role of CD4+ CD25+ FOXP3+ regulatory T cells in the pathogenesis of tuberculosis are very important, providing a new target for immunotherapy and tuberculosis vaccine design as well as clinical application.