活血消癥胶囊与化瘀止痛胶囊分期治疗子宫腺肌病临床研究

目的观察活血消瘕胶囊与化瘀止痛胶囊分期治疗子宫腺肌病的临床疗效及作用机理。方法将68例患者随机分为治疗组（37例，口服活血消瘸胶囊与化瘀止痛胶囊）与对照组（31例，口服米非司酮），比较两组痛经、子宫大小及血清CA125、血液流变性、ET-1的变化。结果治疗后两组痛经症状明显改善，两组疗效相近；两组治疗后子宫体积明显缩小、血清CA125值明显降低；治疗组治疗后血液流变学指标和ET-1水平改善明显。结论活血消瘢胶囊与化瘀止痛胶囊分期治疗子宫腺肌病能缓解痛经症状、缩小增大的子宫，其机理可能与降低血浆中ET-1含量，改善体内血液高凝状态．促进血液微循环，使局部异位内膜萎缩吸收有关。

Clinical Research on the Effect of Huoxuexiaozheng Capsule and Huayuzhitong Capsule in Treating Adenomyosis By Stages

Objective:To explore the clinical effect and its effect mechanism of Huoxuexiaozheng Capsule and Huayuzhitong Capsule on adenomyosis by stages.Methods:68 patients were divided into 2 groups randomly,37 patients of the treatment group were treated with Huoxuexiaozheng Capsule and Huayuzhitong Capsule.31 patients of the control group were treated with mifepristone.Meantime comparing the changes of dysmenorrhea symptom,uterine volumes as well as the level of serum CA125,blood rheology and plasma endothelin-1(ET-1).Results:The symptoms of dysmenorrhea of the 2 groups were obvisously improved after treatment,there was no significant difference between them.The uterine volume of the 2 groups were decreased obviously after treatment .The level of serum CA125 was obviously reduced after treatment.After treatment,the indicators of the treatment group blood rheology improved significantly and the level of ET-1 decreased significantly too.Compared with pretreatment,the difference was significant,compared with the comparison group,the treatment group was better.Conclusions:Huoxuexiaozheng Capsule and Huayuzhitong Capsule in treating adenomyosis by stages can ease the symptom of dysmenorrhea,reduce the increased uterine volume,the mechanism may be releated to the decreased level of ET-1 in plasma,and improving the condition of high condensation in blood,prompting the blood microcirculation as well as prompting the atrophy and absorption of ectopic endometrium.