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Human parathyroid hormone gene (PTH) is on short arm of chromosome 11 |
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| Authors: | S. L. Naylor A. Y. Sakaguchi P. Szoka G. N. Hendy H. M. Kronenberg A. Rich T. B. Shows |
| Affiliation: | 1. Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, 14263, Buffalo, New York 2. Massachusetts General Hospital, 02114, Boston, Massachusetts 3. Institute of Bio-Organic Chemistry, Syntex Corporation, 94304, Palo Alto, California 4. Department of Medicine, The Middlesex Hospital, WIN 8AA, London, England 5. Massachusetts Institute of Technology, 02139, Cambridge, Massachusetts |
| Abstract: | The human gene for parathyroid hormone (PTH) was chromosomally mapped using human-rodent hybrids and Southern filter hybridization of cell hybrid DNA. A recombinant DNA probe containing human PTHcDNA insert (pPTHm122) hybridized to a 3.7-kb fragment in human DNA cleaved with the restriction enzyme EcoRI. By correlating the presence of this fragment in somatic cell hybrid DNA with the human chromosomal content of the hybrid cells, the PTHgene was mapped to the short arm of the chromosome 11. |
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