| 银杏黄酮磷脂复合物自乳化释药系统处方研究 |
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| 引用本文： | 耿旦.银杏黄酮磷脂复合物自乳化释药系统处方研究[J].药学进展,2007,31(9):419-423. |
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| 作者姓名： | 耿旦 |
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| 作者单位： | 广西钦州市第一人民医院药剂科,广西,钦州,535000 |
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| 摘 要： | 目的:优化银杏黄酮磷脂复合物自乳化释药系统处方。方法:以银杏黄酮磷脂复合物在不同种类及比例的油相、表面活性剂中的溶解度为考察指标,筛选自乳化释药系统处方。结果:该处方制备的银杏黄酮磷脂复合物自乳化软胶囊能够迅速溶解并乳化,在蒸馏水、pH6.8磷酸缓冲液和0.1mol/L的HCl中,该系统中的银杏黄酮在45分钟内的溶出度均在80%以上。结论:该自乳化释药系统大大提高了银杏黄酮在水中的溶出度。
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| 关 键 词： | 银杏黄酮 自乳化软胶囊 溶出度 |
| 文章编号： | 1001-5094（2007）09-0420-04 |
| 收稿时间： | 2007-08-07 |
| 修稿时间： | 2007年8月7日 |
Study on Optimizing the Formula of Lecithin Compound Ginkgo Flavone Glycosides Self-emulsifying Drug Delivery System |
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| GENG Dan.Study on Optimizing the Formula of Lecithin Compound Ginkgo Flavone Glycosides Self-emulsifying Drug Delivery System[J].Progress in Pharmaceutical Sciences,2007,31(9):419-423. |
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| Authors: | GENG Dan |
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| Abstract: | Objective: To optimize the formula of lecithin compound Ginkgo Flavone Glycosides self-emul-sifying drug delivery system. Methods: Screening the formula of lecithin compound Ginkgo Flavone Glycosides self-emulsifying drug delivery system based on the compound solubility in various kinds and ratios of surfactants and oil phases. Results: The optimized self-emulsifying soft capsule was quickly dissolved and emulsified. The dissolution of it was over 80% at 45 min in distilled water, pH 6.8 phosphate buffer and 0.1 mol/L HCl. Conclusion: The dissolution of Ginkgo Flavone Glycosides in water is significantly increased by using optimized formula of self-emulsifying drug delivery system. |
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| Keywords: | Ginkgo Flavone Glycosides Self-emulsifying soft capsule Dissolution |
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