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| 高效液相色谱法测定酮甲霜中酮康唑含量 | |
| 引用本文： | 王晓燕,高丹. 高效液相色谱法测定酮甲霜中酮康唑含量[J]. 中国药业, 2010, 19(22): 34-34 |
| 作者姓名： | 王晓燕 高丹 |
| 作者单位： | [1]辽宁倍奇药业有限公司,辽宁丹东118000 [2]中国人民解放军第230医院,辽宁丹东118000 |
| 摘 要： | 目的建立测定酮甲霜中酮康唑含量的高效液相色谱法。方法色谱柱为Diamonsil C18柱（250 mm×4.6 mm,5μm）,流动相为甲醇-水（74∶26）,检测波长为239 nm。结果酮康唑质量浓度在30～70μg/mL范围内与峰面积线性关系良好,回归方程为Y=24 616X-135 469,r=0.999 5（n=5）;平均回收率为99.89%,RSD=0.93%（n=9）。结论该方法简便、准确,可用于酮甲霜中酮康唑的含量测定。 |
| 关 键 词： | 高效液相色谱法 酮甲霜 酮康唑 |
Determination of Ketoconazole in Compound Ketoconazole Cream by HPLC |
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| Wang Xiaoyan,Gao Dan. Determination of Ketoconazole in Compound Ketoconazole Cream by HPLC[J]. China Pharmaceuticals, 2010, 19(22): 34-34 | |
| Authors: | Wang Xiaoyan Gao Dan |
| Affiliation: | 1.Beiqi Pharmaceutical Company,Dandong,Liaoning,China 118000;2.230 Hospital of PLA,Dandong,Liaoning,China 118000) |
| Abstract: | Objective To establish the HPLC method for the determination of ketoconazole in Compound Ketoconazole Cream.Methods The ana-lytical column was Diamonsil C18（250 mm × 4.6 mm,5 μm）.The mobile phase consisted of methanol-water（74 ∶ 26）.The detection wave length was 239 nm.Results The linear range of ketoeonazole was 30-70 μg /mL（r = 0.999 5,n = 5）.The average recovery rate was 99.89%,RSD = 1.40%（n = 9）.Conclusion The method is simple and accurate,which can be used for the quality control of Compound Ketoconazole Cream. |
| Keywords: | HPLC Compound Ketoconazole Cream ketoconazole |
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