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| 西罗莫司局部缓释对成形术后血管壁PAI-1及t-PA表达的影响 | |
| 引用本文： | 鄂亚军,贺能树,范海伦. 西罗莫司局部缓释对成形术后血管壁PAI-1及t-PA表达的影响[J]. 介入放射学杂志, 2011, 20(11): 885-889 |
| 作者姓名： | 鄂亚军 贺能树 范海伦 |
| 作者单位： | 河北大学附属医院介入治疗科;天津医科大学总医院放射科; |
| 摘 要： | 目的 探讨西罗莫司局部缓释对成形术后血管壁纤溶酶原激活物抑制剂1(PAI-1)及组织型纤溶酶原激活剂(t-PA)表达的影响.方法 建立大鼠颈动脉损伤模型,Wistar雄性大鼠30只,分为实验组(20只)及对照组(10只).西罗莫司采取外膜给药,以pluronic F-127为药物释放载体,给药浓度分为高浓度组600 μ... |
| 关 键 词： | 西罗莫司 局部缓释 纤溶酶原激活物抑制剂1 组织型纤溶酶原激活剂 |
The effect of local sustained delivery of sirolimus on the vascular PAI-1 and t-PA expression after angioplasty |
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| E Ya-jun,HE Neng-shu,FAN Hai-lun. The effect of local sustained delivery of sirolimus on the vascular PAI-1 and t-PA expression after angioplasty[J]. Journal of Interventional Radiology, 2011, 20(11): 885-889 | |
| Authors: | E Ya-jun HE Neng-shu FAN Hai-lun |
| Affiliation: | E Ya-jun,HE Neng-shu,FAN Hai-lun.Department of Interventional Radiology,the Affiliated Hospital of Hebei University,Baoding 071000,China |
| Abstract: | Objective To investigate the effect of local sustained delivery of sirolimus on the vascular inhibitor of plasminogen activator-1(PAI-1) and tissue type plasminogen activator(t-PA) expression after angioplasty.Methods Experimental common carotid artery injury model was established in the rats.A total of 30 male Wistar rats were divided into experimental group(n = 20) and control group(n = 10).Adventitial administration of drug was applied.Pluronic F-127 gel containing sirolimus was administered to the expos... |
| Keywords: | sirolimus local sustained delivery inhibitor of plasminogen activator-1 tissue type plasminogen activator |
| 本文献已被 CNKI 等数据库收录！ | |