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| 枸杞多糖作为甲型肝炎疫苗佐剂免疫效果的实验研究 | |
| 引用本文： | 祝峥,钱子刚,胡云章,胡凝珠,朱常成.枸杞多糖作为甲型肝炎疫苗佐剂免疫效果的实验研究[J].云南中医学院学报,2006,29(2):28-30. |
| 作者姓名： | 祝峥 钱子刚 胡云章 胡凝珠 朱常成 |
| 作者单位： | 1. 中国医科大学药学院,辽宁,沈阳,110001 2. 云南中医学院中药学院,云南,昆明,650200 3. 中国医学科学院中国协和医科大学生物学研究所,云南,昆明,650118 |
| 摘 要： | 目的：探讨枸杞多糖（LBPS）作为甲型肝炎（HAV）疫苗佐剂的效果.方法：设HAV含铝佐剂疫苗阳性对照组、HAV不含任何佐剂的抗原阴性对照组、生理盐水空白对照组、LBPS（20mg、10mmg、5mg）3个剂量分别与HAV含铝佐剂疫苗联合、分别与HAV不含任何佐剂的抗原联合成6个实验组免疫小鼠,于免疫后4周、8周、12周、16周、20周尾静脉采血,ELISA法检测小鼠血清抗-HAVIg水平.结果：LBPS 10mg剂量作为HAV疫苗佐剂免疫效果最佳,与阳性、阴性对照组比较差异均有显著性意义.结论：LBPS与铝佐剂有相似的疫苗佐剂效果,且与铝佐剂合用有佐剂协同作用. |
| 关 键 词： | 枸杞多糖 疫苗 佐剂 甲型肝炎 免疫效果 |
| 文章编号： | 1000-2723(2006)02-0028-03 |
| 收稿时间： | 2006-01-05 |
| 修稿时间： | 2006-03-12 |
Experimental Study on Immune Effect of LBP as Adjuvant of HAY Vaccine |
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| ZHU Zheng,QIAN Zi-gang,Hu Yun-zhang,HU Ning-zhu,ZHU Chang-cheng.Experimental Study on Immune Effect of LBP as Adjuvant of HAY Vaccine[J].Journal of Yunnan College of Traditional Chinese Medicine,2006,29(2):28-30. | |
| Authors: | ZHU Zheng QIAN Zi-gang Hu Yun-zhang HU Ning-zhu ZHU Chang-cheng |
| Institution: | 1.School of pharmacy, China Medical University, Shenyang 110001,China; 2.School of Pharmacy ,Yunnan College of TCM, Kunming 650200, China; 3.Institue of Medical Biology , Chinese Academy of Medical Sciences, Peking Union of Medical College , Kunming 650118 |
| Abstract: | ObjectiveTo study the effect of LBPS(the polysacchraide extracted from Lycium barbarum) being used as the adjuvant of HAV vaccine.Method: Immunizing mice with 0.1ml of inactive HAV-antigen(hepatitis A virus) combining with LBPS in doses of 20mg,10mg,5mg respectively and immunizing with 0.1ml of inactive HAV vaccine consisted of Al(OH)3-gel adjuvant combining with LBPS in doses of 20mg,10mg,5mg respectively.ELISA test the anti-HAV(IgG) of the mice after 4,8,12,16 and 20 weeks.Result: LBPS in dose of 10mg has the significant vaccinal adjuvant effect.Conclusion: LBPS is a potent adjuvant applied for human vaccines.The actual function of vaccinal adjuvant effects is comparable of Al(OH)3-gel adjuvant. |
| Keywords: | LBPS Vaccine Adjuvant |
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