生活事件与食管癌发生的病例对照研究

目的 :探讨生活事件与食管癌发生的关系。方法 :采用 1∶2配对病例对照研究。病例组为 1997年 12月安阳县某 3个乡食管癌普查中发现的全部现症食管癌患者。全部病例经细胞学和病理学确诊 ,且全部为鳞癌。对照组从普查中的非食管癌患者中选取。配比条件 :①与病例同性别。②年龄相近 ,与病例年龄相差小于 5岁。③居住地相同 ,与病例同村。结果 :病例组负性事件发生率 (33.9% )显著高于对照组 (14.3% ) ;经单因素和Logistic回归分析发现邻里和睦 (OR =0 15 )、丧偶 (OR =19)、家属重病或亡故 (OR =5 6 3)、经济状况恶化 (OR =4 46 )与食管癌发生有显著联系。结论 :邻里和睦为食管癌保护因素 ,丧偶、家属重病或亡故、经济状况恶化为食管癌危险因素。负性事件为食管癌的危险因素。

Case-control study on relation between life events and occurance of esophagus cancer

To study the relation between life events and occurance ofesophagus cancer. Methods: 1:2 case-controlstudy. The cases were all patients diagnosed by cytology and pathology from an investigation of esophagus cancer in Anyang countryin December, 1997. They all suffered from squamous cell cancer. The controls were chosen fiom the remains in the same investigation. The conditions of control were:① same sex with the case;②same age ( ≤ ± 5 years) with the case;③living in same placewith the case. Results: Negative event rates in case group(33.9% ) were signitieantly higher than that in control group( 14.3 %).By single factor analysis and Logistic model regress analysis, haimony with neighbors ( OR = 0.15 ), bereavement of one' s spouse(OR = 19 ),family's suffering intensive disease or death( OR = 5.63), economic status depravation( OR = 4.46 ) were significantlyrelated with esophagus cancer. Conclusior: Harmony with neighbors is a protective factor of esophagus cancer, bereavement ofone's spouse, family's suffering intensive disease or death, economic status depravation are risk factors. Negative events are riskfactors