糖尿病微血管病变患者炎症因子水平、血浆同型半胱氨酸水平及血液流变学指标变化

目的 为探讨糖尿病视网膜病变严重程度与炎症因子、血浆同型半胱氨酸水平及血液流变学的关系.方法 完全随机选择2型糖尿病患者150例,按有无视网膜病变分为3组:糖尿病无视网膜病变组(NDR)48例、背景型糖尿病视网膜病变组(BDR)52例和增殖型糖尿病视网膜病变组(PDR)50例,检测3组病人的炎症因子、血浆同型半胱氨酸(Hcy)水平和血液流变学指标进行分析.结果 与糖尿病无视网膜病变组比较,背景型糖尿病视网膜病变组与增殖型糖尿病视网膜病变组的炎症因子、血浆Hcy水平、血液流变学指标明显升高,差异有统计学意义(P＜0.01);与背景型糖尿病视网膜病变组比较,增殖型糖尿病视网膜病变组的炎症因子、血浆Hcy水平、血液流变学指标明显升高,差异有统计学意义(P＜0.05).结论 炎症反应、高同型半胱氨酸血症及高粘血症参与了糖尿病视网膜病变的发生和发展过程.

Diabetic Microagniopathy in Patients with Inflammatory Faltors,Plasma Homoly Steine Levels and Changes in Blood Rheology

Aim To evaluate the Changes among inflammatory factor diabetic retinopathy and plasma hyperhomocyssteinemia. Methods 150 type 2 diabetic patients were enrolled,and assigned to three groups: no diabetic retinopathy(NDR),background diabetic retinopathy(BDR) and proliferative diabetic retinopathy(PDR).All patients' inflammatory factors and plasma homocyssteine were measured.All patients'blood rheology analysis were measured. Results The plasma homocyssteine of BDR and PDR were significantly higher than NDR,the...