| 盐酸氟桂利嗪预防月经期偏头痛的疗效观察 |
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| 引用本文： | 许亮,陈春富. 盐酸氟桂利嗪预防月经期偏头痛的疗效观察[J]. 中国疼痛医学杂志, 2011, 17(8). DOI: 10.3969/j.issn.1006-9852.2011.08.010 |
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| 作者姓名： | 许亮 陈春富 |
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| 作者单位： | 山东大学附属省立医院神经内科,济南,250012 |
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| 摘 要： | 目的:探讨盐酸氟桂利嗪(flunarizine hydrochloride)预防月经期偏头痛的临床策略和疗效.方法:选择2008年1月至2009年1月在门诊就诊的月经期偏头痛患者154例,随机分为对照组、5mg组和10mg组.收集患者年龄、头痛时间、偏头痛家族史、头痛严重程度及头痛频率等资料.对照组予以健康宣教,无药物处理,10mg组在月经期前后给予盐酸氟桂利嗪10mg预防治疗(月经期前2天至后3天),5mg组给予5mg预防治疗.比较三组患者头痛程度、发作频率、不良反应和远期疗效.采用视觉模拟评分法(visual analogue scale,VAS)比较干预前后各组头痛程度的变化,分析药物剂量与预防效果的关系.结果:对照组和5mg组比较,两组在头痛程度、频率和复发率方面均无显著性差异(P>0.05);对照组和10mg组比较,两组在头痛程度、频率和复发率方面均有显著性差异(P<0.05);10mg组和5mg组比较,10mg组无痛率明显高于5mg组,两组比较有显著性差异(P<0.05).10mg组发作频率和复发率明显低于5mg组(P<0.05).两组的不良反应无显著性差异(P>0.05).结论:月经期前2天至后3天每天给予盐酸氟桂利嗪10mg控制头痛程度和频率的效果较好,预防复发的远期疗效较好,不良反应无明显增加.
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| 关 键 词： | 月经期偏头痛 盐酸氟桂利嗪 预防 |
PROPHYLACTIC EFFECT OF FLUNARIZINE HYDROCHLORIDE ON PATIENTS WITH MENSTRUAL MIGRAINE |
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| XU Liang,CHEN Chun-Fu. PROPHYLACTIC EFFECT OF FLUNARIZINE HYDROCHLORIDE ON PATIENTS WITH MENSTRUAL MIGRAINE[J]. Chinese Journal of Pain Medicine, 2011, 17(8). DOI: 10.3969/j.issn.1006-9852.2011.08.010 |
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| Authors: | XU Liang CHEN Chun-Fu |
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| Affiliation: | XU Liang,CHEN Chun-Fu(Department of Neurology,Shandong Provincial Hospital,Shandong University,Jinan 250021) |
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| Abstract: | Objective: To observe the effect of flunarizine hydrochloride(sibelium) on menstrual migraine.Methods:Included were 154 out-patient menstrual migraineurs from January 2008 to January 2009.The subjects were randomly divided into control group(n=46),10mg group(n=54) and 5mg group(n=54).The change of the degree of headache,headache attack frequency,adverse effects and protective efficacy were compared after treatment,using visual analogue scale(VAS) as criteria.Results: There were significant differences in th... |
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| Keywords: | Menstrual migraine Flunarizine hydrochloride Prophylaxis |
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