心脏缺血预处理对急性心肌梗死后心律失常的影响

目的 本研究采用动物(新西兰兔)实验方法,探讨心肌缺血预处理(MIP)对急性心肌梗死(AMI)后心律失常的影响.方法 观察AMI组(A组)与MIP组(B组)AMI后的室性心律失常,对两组的室性心律失常发生率进行比较.结果 AMI后24小时内B组频发室性早搏的发生率明显小于A组(P＜0.05),24h后B组行心内电生理检查VT诱发率明显小于A组(P＜0.05).结论 在AMI的家兔模型,B组诱发VT的发生率显著低于A组,提示MIP可以减少AMI的室性心律失常发生.

The Influence of Myocardial Infarction Preconditioning on arrhythmias in Acute Myocardial Infarction

Objective To study the influence of myocardial infarction preconditioning (MIP) on arrhythmias after acute myocardial infarction (AMI) in experimental rabbits. Methods Arrhythmias of group A (rabbits without MIP) and group B (rabbits with MIP) were measured after AMI, and electrophysiologic examination was made to induce ventricular tachycardia (VT) .The gained indexes of two groups were analyzed and compared with each other. Results The rate of ventricular extrasystole of group B was significant lower than that of group in the 24 hour after AMI(p<0.05). The rate of VT of group B was significant lower than that of group A after 24 hour after AMI(p<0.05). Conclusions In AMI models of rabbits.The rate of VT in group B (with MIP) were significant lower than that of group A (without MIP). It was suggested that the MIP decreased the occurrence of VT in AMI.