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Treatment of Adult T Cell Leukaemia by Extracorporeal Photochemotherapy |
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| Authors: | Genjiro Futami Tetsuyuki Kiyokawa Kazunari Yamaguchi Toshinoriishii Munashi Oishi Masayoshi Jono Tatsuki Arao Kiyoshi Takatsuki |
| Affiliation: | a Department of Internal Medicine, Kumamoto University, Kumamoto, Japanb Department of Blood Transfusion Service, Kumamoto University, Kumamoto, Japanc Department of Medical Technology, College of Medical Science, Kumamoto University, Kumamoto, Japand Department of Dermatology, Kumamoto University Medical School, Kumamoto University, Kumamoto, Japan |
| Abstract: | Four patients with chronic or smouldering type adult T cell leukaemia (ATL) were treated by extracorporeal photochemotherapy (photopheresis). From 4 to 8 months after starting photo-pheresis, skin lesions with ATL cell infiltration began to disappear. Cell surface markers in three patients showed improvement. In one patient, a serial decrease of soluble interleukin-2 receptor levels (950 U/ml to 620) in the serum was observed after 4 months. This pilot study suggests that photopheresis may be successfully applied in ATL. It is still necessary to continue follow-up observations in these patients and to treat a larger number of cases, before definite conclusions can be drawn in the future |
| Keywords: | Adult T cell leukaemia ATL leukaemia extracorporeal photochemotherapy |
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